Results 101 to 110 of about 255,990 (266)

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Maternal Antibody of DOC Pelung from Combine ND-Vaccinated Hen

Animal Production: Indonesian Journal of Animal Production, 2003
A research entitled “Maternal Antibody of Pelung Day Old Chicken From Combine ND-Vaccinated Hen” has been done at Deddy Farm, Brebes. The materials were 25 hens and 5 cocks parental Pelung and 50 DOC (day old chick) hatched from those parent.
D Prabowo
doaj  

Long-term COVID-19 vaccine- and Omicron infection-induced humoral and cell-mediated immunity

Frontiers in Immunology
IntroductionMutations occurring in the spike (S) protein of SARS-CoV-2 enables the virus to evade COVID-19 vaccine- and infection-induced immunity.MethodsHere we provide a comprehensive analysis of humoral and cell-mediated immunity in 111 healthcare ...
Milja Belik, Arttu Reinholm, Pekka Kolehmainen, Jemna Heroum, Sari Maljanen, Eda Altan, Pamela Österlund, Larissa Laine, Olli Ritvos, Arja Pasternack, Rauno A. Naves, Alina Iakubovskaia, Alex-Mikael Barkoff, Qiushui He, Qiushui He, Johanna Lempainen, Paula A. Tähtinen, Lauri Ivaska, Lauri Ivaska, Pinja Jalkanen, Ilkka Julkunen, Ilkka Julkunen, Ilkka Julkunen, Laura Kakkola, Laura Kakkola   +24 more
doaj   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

The elusive goal of COVID-19 vaccine immunity. [PDF]

Lancet Respir Med, 2023
Abu-Raddad LJ, Chemaitelly H.
europepmc   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

Nano‐Confined Radical Anion as An NIR‐II Photothermal Immunogenic Amplifier for In Situ Cancer Vaccination

Advanced Science, EarlyView.
A nano‐confined radical anion acts as a photothermal immunogenic amplifier. Kinetically stabilized nanoparticles couple high near‐infrared‐II (NIR‐II) photothermal efficacy with glutathione (GSH) depletion to boost reactive oxygen species (ROS) and immunogenic cell death (ICD).
Mengxin Mu, Mengyu Guo, Jun Guan, Xiaofeng He, Mingdi Hu, Fene Gao, Klaus Müllen, Chendong Ji, Chunying Chen, Meizhen Yin   +9 more
wiley   +1 more source

Influenza vaccination post-COVID-19 expands vaccine-specific effector CD4 T-cells and Tregs under positive influence of host trained innate immunity

npj Vaccines
SARS-CoV-2 immunity and innate immune training may influence influenza vaccine immunogenicity. We investigated this in India. Adult volunteers with hybrid SARS-CoV-2 immunity were administered FluarixTM Tetra (GlaxoSmithKlein) 2022/2023 NH Vaccine in ...
Hima Bindhu, Srabanti Rakshit, Vasista Adiga, Asma Ahmed, Nirutha Chetan Kumar, Maria Macrina, Himanshu Tripathi, Francesca Vanni, Emanuele Montomoli, Sweety Samal, Sneha Raj, Preeti Vishwakarma, George D. Souza, Shruthi Sasidharan, Mary Dias, Timothy Tree, Annapurna Vyakarnam   +16 more
doaj   +1 more source

A Pathology‐Instructed Theranostic Platform with Mechanoadaptive and ROS‐Powered Nanobreathing Functions for Precision Myocardial Repair

Advanced Science, EarlyView.
We developed a pH responsive theranostic serum albumin hydrogel named BST, functionalized with MRI and CT probes and loaded with mitochondria targeted CAT‐SOD nanogels, that rapidly self repairs and mechanically stabilizes the infarcted myocardium, releases therapeutic nanogels and albumin under hypoxia induced acidosis to clear mitochondrial ROS ...
Zheng Luo, Cui Yang, Liuzhou Mao, Panqin Ma, Chiyu Jia, Karen Yuanting Tang, Xian Jun Loh, Yun‐Long Wu   +7 more
wiley   +1 more source