Results 121 to 130 of about 255,990 (266)

Simulating influenza epidemics with waning vaccine immunity. [PDF]

Medicine (Baltimore), 2021
Chen CJ, Stanciu AC.
europepmc   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models. [PDF]

Vaccine, 2023
Freitag TL, Fagerlund R, Karam NL, Leppänen VM, Ugurlu H, Kant R, Mäkinen P, Tawfek A, Jha SK, Strandin T, Leskinen K, Hepojoki J, Kesti T, Kareinen L, Kuivanen S, Koivulehto E, Sormunen A, Laidinen S, Khattab A, Saavalainen P, Meri S, Kipar A, Sironen T, Vapalahti O, Alitalo K, Ylä-Herttuala S, Saksela K.   +26 more
europepmc   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Unravelling the enhanced vaccine immunity by heterologous KCONVAC/Ad5-nCoV COVID-19 vaccination. [PDF]

Signal Transduct Target Ther, 2022
Zhao W, Zhao H, Huang B, Zhao T, Wang L, Zhang J, Yang Y, Tang X, Tan W, Lin A.   +9 more
europepmc   +1 more source

Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection

Animal Models and Experimental Medicine, EarlyView.
A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang, Shicheng Wan, Yanmin Guo, Hongyu Han, Fei Luo, Dongmei Jiang, Xiaorong Yang, Quanhai Pang, Haisheng Yu, Jinlian Hua   +9 more
wiley   +1 more source

Exploring the Impact of Adjuvants on Vaccine Immunity Through Hematopoietic Cells. [PDF]

Vaccines (Basel)
Ji Y, Bekkari K, Shardar M, Walford GA, Kim S, Liu Y, Read-Button W, Tracy K, Kriss J, Barr C, Wolfle M, Kummar S, LaPorta C, Graham R, Chen L, Smith WJ, Bakshi K, Murgolo N, Sullivan NL.   +18 more
europepmc   +1 more source

Directed attenuation to enhance vaccine immunity. [PDF]

PLoS Comput Biol, 2021
Antia R, Ahmed H, Bull JJ.
europepmc   +1 more source

Advances and perspectives in animal models of human hepatitis A virus

Animal Models and Experimental Medicine, EarlyView.
Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li, Pei‐Yu Jiang, Hui Zhao, Cheng‐Feng Qin   +3 more
wiley   +1 more source

Vaccine Immunity Against Pneumococcus in Children With Cochlear Implants. [PDF]

Pediatr Infect Dis J
Hominal A, Gualtieri R, Lemaitre B, Pósfay-Barbe KM, Cao-Van H, Blanchard-Rohner G.   +5 more
europepmc   +1 more source