Results 131 to 140 of about 255,990 (266)

Clinical form of asthma and vaccine immunity in preschoolers. [PDF]

Postepy Dermatol Alergol, 2021
Bednarek A, Bodajko-Grochowska A, Klepacz R, Szczekala K, Zarzycka D, Emeryk A.   +5 more
europepmc   +1 more source

Dose‐dependent pathogenicity and inflammatory imbalance in severely immunodeficient mice infected with mpox virus

Animal Models and Experimental Medicine, EarlyView.
This study establishes an NPG (NOD.Cg‐Prkdcscid Il2rgtm1/Vst) mouse model for severe monkeypox virus infection in immunocompromised hosts, demonstrating dose‐dependent disease severity and revealing that unbalanced pro‐inflammatory cytokine release drives pathogenesis, providing insights for therapeutic interventions. Abstract The global spread of mpox
Na Li, Ziqing Jia, Zhe Cong, Jianrong Ma, Jiahan Lu, Yongzhi Hou, Fei Wang, Jiasen Yang, Ting Chen, Jingjing Zhang, Dong Zhang, Jing Xue   +11 more
wiley   +1 more source

Establishing long-lasting vaccine immunity: insights from mRNA and adjuvanted protein platforms. [PDF]

NPJ Vaccines
Pineda-Peña AC, Hasegawa K, Pavot V, Berry C, Combadière B, Cortes-Garcia G, McDermott AB, Sridhar S.   +7 more
europepmc   +1 more source

Will vaccine immunity last? [PDF]

New Sci, 2020
Lawton G.
europepmc   +1 more source

GM-CSF⁺ Tc17 cells are required to bolster vaccine immunity against lethal fungal pneumonia without causing overt pathology. [PDF]

Cell Rep, 2022
Mudalagiriyappa S, Sharma J, Vieson MD, Nanjappa SG.   +3 more
europepmc   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Hepatitis B vaccine immunity in healthcare workers: Seroprotection and cellular immune signatures of waning response. [PDF]

J Family Med Prim Care
Khargekar NC, Pujari V, Athalye S, Mallik A, Jodhawat N, Shinde S, Banerjee A.   +6 more
europepmc   +1 more source

Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1. [PDF]

J Immunol, 2022
Cusimano GM, Gary EN, Bell MR, Warner BM, Connors J, Tursi NJ, Ali AR, Zhang S, Canziani G, Taramangalam B, Gordon EA, Chaiken IM, Wootton SK, Smith T, Ramos S, Kobasa D, Weiner DB, Kutzler MA, Haddad EK.   +18 more
europepmc   +1 more source

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Chemically Regulated STING‐Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity

Angewandte Chemie, EarlyView.
All three diastereoisomers of an esterase‐sensitive phosphotriester dCDN prodrug demonstrate improved activity. The (Rp,Rp) diastereoisomer shows the highest activity with an EC50 of 1.7 nM in STING activation and displays the most pronounced antitumor activity via intravenous administration, significantly suppressing tumor proliferation, extending the
Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai, Yao Zhang, Dejun Ma, Rong Xiang, Shibo Li, Zhen Xi   +14 more
wiley   +2 more sources