Results 51 to 60 of about 2,444,578 (297)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Progress and Challenges in Measles and Rubella Elimination in the WHO European Region

Vaccines
The elimination of both measles and rubella remains a priority for all 53 Member States of the World Health Organization (WHO) European Region. To provide an update on the epidemiological status of measles and rubella in the Region, we reviewed ...
Mark Muscat, Myriam Ben Mamou, Catharina Reynen-de Kat, Dragan Jankovic, José Hagan, Simarjit Singh, Siddhartha Sankar Datta   +6 more
doaj   +1 more source

Genomic characterization of Haemophilus influenzae: a focus on the capsule locus

BMC Genomics, 2019
Background Haemophilus influenzae (Hi) can cause invasive diseases such as meningitis, pneumonia, or sepsis. Typeable Hi includes six serotypes (a through f), each expressing a unique capsular polysaccharide.
Caelin C. Potts, Nadav Topaz, Lorraine D. Rodriguez-Rivera, Fang Hu, How-Yi Chang, Melissa J. Whaley, Susanna Schmink, Adam C. Retchless, Alexander Chen, Edward Ramos, Gregory H. Doho, Xin Wang   +11 more
doaj   +1 more source

Addressing Determinants of Immunization Inequities Requires Objective Tools to Devise Local Solutions

Vaccines, 2023
Universal immunization substantially reduces morbidity and mortality from vaccine-preventable diseases. In recent years, routine immunization coverage has varied considerably among countries across the WHO European Region, and among different populations
Siddhartha Sankar Datta, Federico Martinón-Torres, Nino Berdzuli, Niyazi Cakmak, Michael Edelstein, Simon Cottrell, Mark Muscat   +6 more
doaj   +1 more source

INCIDENCE OF VACCINE PREVENTABLE DISEASES IN PEDIATRIC POPULATION OF LATVIA [PDF]

, 2016
Childhood and adolescent immunizations are one of the most effective means of preventing such serious diseases as diphtheria, pertussis, rubella etc. These infectious diseases are termed as vaccine preventable diseases because vaccination continues to be
Meiere, Anija, Klagisa, Renata
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The impact of multiplex panel testing on ascertainment of pertussis-attributable, non-infant deaths: national surveillance from England

Journal of Clinical Microbiology
Understanding the burden of pertussis and pertussis-related mortality is important in enabling a better understanding of population vulnerability and supporting vaccination program planning.
Catherine Sandford Alber, Emer Cullen, Sonia Ribeiro, David J. Litt, Gayatri Amirthalingam, Helen Campbell, Sharif A. Ismail   +6 more
doaj   +1 more source

BMScan: using whole genome similarity to rapidly and accurately identify bacterial meningitis causing species

BMC Infectious Diseases, 2018
Background Bacterial meningitis is a life-threatening infection that remains a public health concern. Bacterial meningitis is commonly caused by the following species: Neisseria meningitidis, Streptococcus pneumoniae, Listeria monocytogenes, Haemophilus ...
Nadav Topaz, Dave Boxrud, Adam C. Retchless, Megan Nichols, How-Yi Chang, Fang Hu, Xin Wang   +6 more
doaj   +1 more source

Evidence and guidance on vaccine safety and effectiveness in subpopulations [PDF]

, 2011
This dissertation examines post-licensing vaccine safety and effectiveness against two major respiratory diseases in specific subpopulations, with emphasis on safety.
Mak, Tippi
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source