Results 41 to 50 of about 183,150 (159)

Injection of α-syn-98 Aggregates Into the Brain Triggers α-Synuclein Pathology and an Inflammatory Response

Frontiers in Molecular Neuroscience, 2019
Pathological aggregation of α-synuclein (α-syn) is a major component of Lewy bodies (LB), which play a central role in pathogenesis of Parkinson’s disease (PD). Differential expression of α-syn isoforms has been shown in PD. Isoform α-syn-98 is generated
Tingfu Du, Tingfu Du, Tingfu Du, Zhengcun Wu, Zhengcun Wu, Haiyu Luo, Haiyu Luo, Shuaiyao Lu, Shuaiyao Lu, Kaili Ma, Kaili Ma, Kaili Ma   +11 more
doaj   +1 more source

Vaccine Safety

, 2017
“Are vaccines safe?” has become one of the most hotly contested and politically charged questions in contemporary culture, fueled in no small part by voracious online debates, peer-to-peer influence, and source information of varying degrees of quality and accuracy.
C. John Clements, Glenda L. Lawrence, Kristine K. Macartney   +2 more
openaire   +2 more sources

Repeated-dose toxicity and immunogenicity evaluation of norovirus P particle-based rotavirus vaccine in juvenile cynomolgus monkeys

Frontiers in Immunology
IntroductionRotavirus remains a major cause of mortality among young children worldwide, underscoring the urgent need for new vaccines. The present study evaluated the repeated-dose toxicity and immunogenicity of a bivalent rotavirus subunit candidate ...
Wei Pan, Wei Pan, Yingjie Cheng, Yingjie Cheng, Xiaojing Shi, Xiaojing Shi, Yunxiang Chen, Yunxiang Chen, Yunxiang Chen, Cong Xu, Cong Xu, Zhengbiao Yang, Zhengbiao Yang, Qijiong Lu, Qijiong Lu, Qijiong Lu, Lei Wen, Lei Wen, Lei Wen, Fang Liu, Fang Liu, Tingli Bian, Tingli Bian, Li Qin, Li Qin, Shuizhen Pan, Shuizhen Pan, Ying Chen, Ying Chen, Changwei Wu, Changwei Wu, Lijiang Zhang, Lijiang Zhang, Lijiang Zhang, Hongzhong Yang, Hongzhong Yang, Hongzhong Yang   +36 more
doaj   +1 more source

Collaboration within the global vaccine safety surveillance ecosystem during the COVID-19 pandemic: lessons learnt and key recommendations from the COVAX Vaccine Safety Working Group

BMJ Global Health
This analysis describes the successes, challenges and opportunities to improve global vaccine safety surveillance as observed by the Vaccine Safety Working Group from its role as a platform of exchange for stakeholders responsible for monitoring the ...
Rebecca E Chandler, James Milligan, Emmanuelle Espie, Katharina Hartmann, Madhava Ram Balakrishnan, Daniel Brasseur, Philip Bryan, Corinne Jouquelet-Royer, Linda Nesbitt, Shanthi Pal, Alexander Precioso, Paulo Takey, Robert T Chen   +12 more
doaj   +1 more source

Enhanced passive safety surveillance of standard-dose and high-dose influenza vaccines in Finland and Germany 2023–24 season

Human Vaccines & Immunotherapeutics
Enhanced Passive Safety Surveillance was used to detect safety signals before the peak period of immunization with quadrivalent inactivated influenza vaccines (IIV4) in Finland (standard dose [SD]) and Germany (high dose [HD]) in the 2023–24 season.
Marina Amaral de Avila Machado, Sophie Gallo, Alexander Goldstein, Parth Vachhani, Reddappa Maniganahally Byrareddy, Anu Kantele, Hanna Välimaa, Jörg Schelling   +7 more
doaj   +1 more source

Communicating COVID-19 Vaccine Safety: Knowledge and Attitude Among Residents of South East, Nigeria

Infection and Drug Resistance, 2021
Luke Ifeanyi Anorue, Alphonsus Chukwuma Ugwu, Stanley Uzoamaka Ugboaja, Uzoma O Nwabunze, Chinyere Christiana Ugwulor-Onyinyechi, Chioma Njoku Department of Mass Communication, University of Nigeria, Nsukka, NigeriaCorrespondence: Chioma NjokuDepartment ...
Anorue LI, Ugwu AC, Ugboaja SU, Nwabunze UO, Ugwulor-Onyinyechi CC, Njoku C   +5 more
doaj  

Vaccine Safety International Monitoring

Безопасность и риск фармакотерапии, 2019
Vaccine safety is an important aspect of mass immunization of the population. Adverse reactions that occur following vaccination result in a decrease in public confidence. The aim of this research was to identify information on the development of adverse
M. A. Darmostukova, I. I. Snegireva, N. Yu. Velts, A. S. Kazakov, R. N. Alyautdin   +4 more
doaj   +1 more source

Editorial: Immunological aspects of vaccine safety

Frontiers in Immunology, 2023
Michael Vajdy, Barbara A. Rath, Kawsar R. Talaat   +2 more
doaj   +1 more source

Strategies for identifying and using diverse global health data: perspectives from data searching and meta-analyses on antimicrobial resistance

Discover Public Health
Searching for and utilizing biomedical data is an essential part of most research efforts, including in public health, and almost always involves use of major online databases.
Danielle M. Venne, David M. Hartley, C. Scott Dorris, Laura M. Torres, Marissa D. Malchione, Elizabeth A. Mitgang, Jesse L. Goodman   +6 more
doaj   +1 more source

Immunogenicity and efficacy of an mRNA vaccine expressing a virus-like particle spike antigen against SARS-CoV-2

npj Vaccines
The COVID-19 pandemic spurred mRNA vaccine innovation, but new SARS-CoV-2 variants highlight the need for vaccines with improved potency and durability.
Jason P. Laliberte, Yingyun Cai, Tara Kenny, Yi Zhang, Kuishu Ren, Kim Rosenthal, Daniel Flores, Richard Roque, Oliver Acton, Vanessa Cadevilla Peano, Noel Janney, Vinita Puri, Sarah Siddiqui, Angela Pack, Giune Padilla, Seme Diallo, Hibret Adissu, Rakesh Choudhary, Hawley Pruitt, Yi-Han Cheng, George Thom, Michael Newton, Cheyne Kurokawa, Johnathan Guest, Phillip Swanson, Yueh-Ming Loo, Joseph R. Francica, Wade Blair, Mark Esser   +28 more
doaj   +1 more source