Results 51 to 60 of about 2,756,439 (291)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Preclinical immunogenicity and safety of hemagglutinin-encoding modRNA influenza vaccines

npj Vaccines
Seasonal epidemics of influenza viruses are responsible for a significant global public health burden. Vaccination remains the most effective way to prevent infection; however, due to the persistence of antigenic drift, vaccines must be updated annually.
Teresa Hauguel, Amy Sharma, Emily Mastrocola, Susan Lowry, Mohan S. Maddur, Cheng Hui Hu, Swati Rajput, Allison Vitsky, Shambhunath Choudhary, Balasubramanian Manickam, Ivna De Souza, Yana Chervona, Raquel Munoz Moreno, Charisse Abdon, Larissa Falcao, Kristin Tompkins, Deanne Illenberger, Rachel Smith, Fanyu Meng, Shuai Shi, Kari Sweeney Efferen, Victoria Markiewicz, Cinthia Umemoto, Jianfang Hu, Wei Chen, Ingrid Scully, Cynthia M. Rohde, Annaliesa S. Anderson, Pirada Suphaphiphat Allen   +28 more
doaj   +1 more source

First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. [PDF]

, 2011
BACKGROUND\ud \ud An ongoing phase 3 study of the efficacy, safety, and immunogenicity of candidate malaria vaccine RTS,S/AS01 is being conducted in seven African countries.\ud \ud METHODS\ud \ud From March 2009 through January 2011, we enrolled 15,460 ...
Machera, Francisca, Abdulla, Salim, Sillman, Marla, Maingi, Charity, Aide, Pedro, Hamad, AS, Sambian, D, Kremsner, Peter Gottfried, Mordmüller, B, Conzelmann, Cornelia, Maingi, C, Sylverken, J, Adjei, George, Sandrine, Y, Abdul, Omari, Owusu-Ofori, R, Drakeley, C, Ansong, D, Leach, Amanda, Urassa, AM, Radford, A, Kayan, K, Methogo, Barbara Gaelle Nfono Ondo, Carter, T, Bejon, Philip, Gondi, Stacey, Chome, Nelecy, Akoo, P, Doucka, Yannick, Aponte, John J, Guerra, Yolanda, Aponte, JJ, Valea, I, Chandramohan, Daniel, null null, Alonso, P, Jones, David, Liheluka, Edwin, Sillman, M, Loucq, Christian, Malabeja, A, Omoto, Jackton, Agnandji, ST, Nyakuipa, Dalitso, Quelhas, D, Flamen, Arnaud, Jongert, Erik, Ahmed, S, Otieno, Walter, Bassat, Quique, Slutsker, L, Mordmüller, Benjamin, Slutsker, Laurence, Agyekum, Alex, Ofori-Anyinam, Opokua, Kaboré, W, Hamad, Ali Said, Doucka, Y, Wasuna, Ruth, Vansadia, Preeti, Otieno, A, Tahita, MC, Savarese, B, Lanaspa, Miguel, Ogutu, B, Gitaka, J, Lang, T, Drakeley, Chris, Issifou, S, Shomari, M, Abdul, O, Otieno, L, Otieno, K, Nyakuipa, D, Kaboré, William, Asante, Isaac, Gesase, Samwel, Cohen, Joe, Aide, P, Shubis, Kafuruki, Ogutu, Bernhards, Agnandji, Selidji Todagbe, Otieno, Lucas, Sambian, David, Kilavo, H, Adjei, S, Greenwood, B, Ansong, Daniel, Lell, Bertrand, Chandramohan, D, Awino, Norbert, Asante, KP, Rettig, T, Adjei, G, Gitaka, Jesse, Carter, Terrell, Juma, Omar, Gondi, S, Ouédraogo, JB, Tinto, H, Lemnge, M, Shomari, Mwanajaa, Guiguemdé, RT, Hoffman, Irving, Mvalo, T, Mtoro, Ali, Schellenberg, David, Quelhas, Diana, Radford, Afiya, Minja, Rose, Lievens, M, Cohen, J, Sorgho, H, Kerubo, Christine, Bawa, J, Theander, Thor, Ahmed, Saumu, Juma, O, Odero, Chris, Vekemans, Johan, Nkomo, Ruthendo, Muturi-Kioi, Vincent, Mvalo, Tisungane, RTS,S Clinical Trials Partnership, Theander, T, Tsofa, Benjamin, Dosoo, David, Ouédraogo, Jean Bosco, Mwangoka, Grace, Kremsner, PG, Jumbe, A, Otieno, W, Boateng, HO, Jongert, E, Rettig, Theresa, Conzelmann, C, Sorgho, Hermann, Flamen, A, Lell, B, Bejon, P, Ouédraogo, Sayouba, Osei-Kwakye, Kingsley, Agbenyega, Tsiri, Owira, Victorine, Nekoye, O, Issifou, Saadou, Muturi-Kioi, V, Ayamba, S, Kariuki, Simon, Methogo, BG, Oneko, Martina, Otieno, Kephas, Olotu, Ally, Lapierre, Didier, Fernandes, José Francisco, Macete, E, Owira, V, Ali, Ali Mohammed, Boahen, Owusu, Minja, R, Oneko, M, Onyango, Agnes Akoth, Leach, A, Liheluka, E, Sylverken, Justice, Lusingu, J, Hamel, Mary J, Salim, N, Vansadia, P, Owusu-Agyei, S, Njuguna, P, Kamthunzi, P, Macete, Eusébio, Mwangoka, G, Asante, Kwaku Poku, Owusu-Agyei, Seth, Fernandes, JF, Lemnge, Martha, Chintedza, J, Nhamuave, A, Ayamba, Samuel, Hamel, MJ, Msika, Albans, Kayan, Kingsley, Leboulleux, D, Alonso, Pedro, Kamthunzi, Portia, Marsh, K, Otieno, Allan, Kerubo, C, Ballou, W Ripley, Nekoye, Otsyula, Lanaspa, M, Shubis, K, Lievens, Marc, Sykes, A, Abossolo, Béatrice Peggy, Lapierre, D, Mandjate, Sofia, Chome, N, Ofori-Anyinam, O, Dosoo, D, Martinson, F, Marsh, Kevin, Urassa, Alwisa Martin, Mahende, Coline, Abdulla, S, Tsofa, B, Ali, AM, Boahen, O, Bassat, Q, Bawa, John, Sandrine, Yara, Osei-Kwakye, K, Peshu, N, Akoo, Pauline, Adjei, Samuel, Njuguna, Patricia, Jumbe, Allan, Williamson, John, Agbenyega, T, Sacarlal, J, Mtoro, A, Leboulleux, Didier, Greenwood, Brian, Malabeja, Anangisye, Wasuna, R, Chilengi, Roma, Schellenberg, D, Nhamuave, Arlindo, Guiguemdé, Robert Tinga, Awino, N, Tinto, Halidou, Tahita, Marc Christian, Mandjate, S, Asante, I, Martinson, Francis, Abossolo, BP, Tanner, M, Williamson, J, Kariuki, S, Machera, F, Kilavo, Hassan, Jones, D, Lusingu, John, Boateng, Harry Owusu, Chintedza, Joseph, Soulanoudjingar, Solange Solmeheim, Lang, Trudie, Sacarlal, Jahit, Gesase, S, Mahende, C, Ouédraogo, S, Bruls, Myriam, Guerra, Y, Msika, A, Soulanoudjingar, SS, Loucq, C, The RTS, S. Clinical Trials Partnership, Sykes, Alma, Agyekum, A, Owusu, L, Vekemans, J, Owusu, Larko, Odero, C, Tanner, Marcel, Laserson, Kayla F, Peshu, Norbert, Savarese, Barbara, Owusu-Ofori, Ruth, Omoto, J, Valea, Innocent, Chilengi, R, Bruls, M, D'Alessandro, Umberto, Onyango, AA, Hoffman, I, Salim, Nahya, Laserson, KF, D'Alessandro, U, Ballou, WR, Nkomo, R, Olotu, A   +282 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Design of a phase III multicenter trial to evaluate the efficacy of the RTS,S/AS01 malaria vaccine in children across diverse transmission settings in Africa. [PDF]

, 2011
BACKGROUND\ud \ud GlaxoSmithKline Biologicals and the PATH Malaria Vaccine Initiative are working in partnership to develop a malaria vaccine to protect infants and children living in malaria endemic regions of sub-Saharan Africa, which can be delivered ...
Amanda Leach, Vekemans Johan, Savarese Barbara, Abdulla, Salim, Loucq, Christian, Salim Abdulla, Cahill Conor, Owusu-Agyei, Seth, Macete, Eusebio, Lievens Marc, Njuguna, Patricia, Marc Lievens, Christian Loucq, Ofori-Anyinam Opokua, Leach, Amanda, Njuguna Patricia, Vekemans, Johan, Patricia Njuguna, Cahill, Conor, Macete Eusebio, Barbara Savarese, Savarese, Barbara, Seth Owusu-Agyei, Owusu-Agyei Seth, Opokua Ofori-Anyinam, Ballou, W Ripley, Abdulla Salim, Clinical Trials Partnership Committee, Lievens, Marc, Ofori-Anyinam, Opokua, null null, Leach Amanda, Eusebio Macete, Conor Cahill, Ballou W Ripley, Loucq Christian, Johan Vekemans, W Ripley Ballou   +37 more
core   +1 more source

Advancing Stroke Clinical Trials Using Community Engagement and Implementation Science Approaches

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Stroke clinical trials are essential for advancing stroke care but can face challenges with recruitment, retention, clinical relevance, and translation into real‐world practice. We propose that integrating community engagement and implementation science approaches into stroke trials can help address these needs.
Lesli E. Skolarus, Devin L. Brown, Bernadette Boden‐Albala   +2 more
wiley   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Changes in vaccine attitudes and recommendations among US Healthcare Personnel during the COVID-19 pandemic

npj Vaccines
A recommendation from healthcare personnel (HCP) is a strong predictor of vaccination. This study aimed to measure how HCP vaccine attitudes and recommendations changed during the COVID-19 pandemic. HCP were surveyed in January 2023 using a double opt-in
Matthew Z. Dudley, Holly B. Schuh, Amanda Forr, Jana Shaw, Daniel A. Salmon   +4 more
doaj   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source