Results 51 to 60 of about 2,769,024 (292)
Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic +9 morewiley +1 more sourcePreclinical immunogenicity and safety of hemagglutinin-encoding modRNA influenza vaccines
npj VaccinesSeasonal epidemics of influenza viruses are responsible for a significant global public health burden. Vaccination remains the most effective way to prevent infection; however, due to the persistence of antigenic drift, vaccines must be updated annually. Teresa Hauguel, Amy Sharma, Emily Mastrocola, Susan Lowry, Mohan S. Maddur, Cheng Hui Hu, Swati Rajput, Allison Vitsky, Shambhunath Choudhary, Balasubramanian Manickam, Ivna De Souza, Yana Chervona, Raquel Munoz Moreno, Charisse Abdon, Larissa Falcao, Kristin Tompkins, Deanne Illenberger, Rachel Smith, Fanyu Meng, Shuai Shi, Kari Sweeney Efferen, Victoria Markiewicz, Cinthia Umemoto, Jianfang Hu, Wei Chen, Ingrid Scully, Cynthia M. Rohde, Annaliesa S. Anderson, Pirada Suphaphiphat Allen +28 moredoaj +1 more sourceFirst results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. [PDF]
, 2011 BACKGROUND\ud
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An ongoing phase 3 study of the efficacy, safety, and immunogenicity of candidate malaria vaccine RTS,S/AS01 is being conducted in seven African countries.\ud
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METHODS\ud
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From March 2009 through January 2011, we enrolled 15,460 ...Machera, Francisca, Abdulla, Salim, Sillman, Marla, Maingi, Charity, Aide, Pedro, Hamad, AS, Sambian, D, Kremsner, Peter Gottfried, Mordmüller, B, Conzelmann, Cornelia, Maingi, C, Sylverken, J, Adjei, George, Sandrine, Y, Abdul, Omari, Owusu-Ofori, R, Drakeley, C, Ansong, D, Leach, Amanda, Urassa, AM, Radford, A, Kayan, K, Methogo, Barbara Gaelle Nfono Ondo, Carter, T, Bejon, Philip, Gondi, Stacey, Chome, Nelecy, Akoo, P, Doucka, Yannick, Aponte, John J, Guerra, Yolanda, Aponte, JJ, Valea, I, Chandramohan, Daniel, null null, Alonso, P, Jones, David, Liheluka, Edwin, Sillman, M, Loucq, Christian, Malabeja, A, Omoto, Jackton, Agnandji, ST, Nyakuipa, Dalitso, Quelhas, D, Flamen, Arnaud, Jongert, Erik, Ahmed, S, Otieno, Walter, Bassat, Quique, Slutsker, L, Mordmüller, Benjamin, Slutsker, Laurence, Agyekum, Alex, Ofori-Anyinam, Opokua, Kaboré, W, Hamad, Ali Said, Doucka, Y, Wasuna, Ruth, Vansadia, Preeti, Otieno, A, Tahita, MC, Savarese, B, Lanaspa, Miguel, Ogutu, B, Gitaka, J, Lang, T, Drakeley, Chris, Issifou, S, Shomari, M, Abdul, O, Otieno, L, Otieno, K, Nyakuipa, D, Kaboré, William, Asante, Isaac, Gesase, Samwel, Cohen, Joe, Aide, P, Shubis, Kafuruki, Ogutu, Bernhards, Agnandji, Selidji Todagbe, Otieno, Lucas, Sambian, David, Kilavo, H, Adjei, S, Greenwood, B, Ansong, Daniel, Lell, Bertrand, Chandramohan, D, Awino, Norbert, Asante, KP, Rettig, T, Adjei, G, Gitaka, Jesse, Carter, Terrell, Juma, Omar, Gondi, S, Ouédraogo, JB, Tinto, H, Lemnge, M, Shomari, Mwanajaa, Guiguemdé, RT, Hoffman, Irving, Mvalo, T, Mtoro, Ali, Schellenberg, David, Quelhas, Diana, Radford, Afiya, Minja, Rose, Lievens, M, Cohen, J, Sorgho, H, Kerubo, Christine, Bawa, J, Theander, Thor, Ahmed, Saumu, Juma, O, Odero, Chris, Vekemans, Johan, Nkomo, Ruthendo, Muturi-Kioi, Vincent, Mvalo, Tisungane, RTS,S Clinical Trials Partnership, Theander, T, Tsofa, Benjamin, Dosoo, David, Ouédraogo, Jean Bosco, Mwangoka, Grace, Kremsner, PG, Jumbe, A, Otieno, W, Boateng, HO, Jongert, E, Rettig, Theresa, Conzelmann, C, Sorgho, Hermann, Flamen, A, Lell, B, Bejon, P, Ouédraogo, Sayouba, Osei-Kwakye, Kingsley, Agbenyega, Tsiri, Owira, Victorine, Nekoye, O, Issifou, Saadou, Muturi-Kioi, V, Ayamba, S, Kariuki, Simon, Methogo, BG, Oneko, Martina, Otieno, Kephas, Olotu, Ally, Lapierre, Didier, Fernandes, José Francisco, Macete, E, Owira, V, Ali, Ali Mohammed, Boahen, Owusu, Minja, R, Oneko, M, Onyango, Agnes Akoth, Leach, A, Liheluka, E, Sylverken, Justice, Lusingu, J, Hamel, Mary J, Salim, N, Vansadia, P, Owusu-Agyei, S, Njuguna, P, Kamthunzi, P, Macete, Eusébio, Mwangoka, G, Asante, Kwaku Poku, Owusu-Agyei, Seth, Fernandes, JF, Lemnge, Martha, Chintedza, J, Nhamuave, A, Ayamba, Samuel, Hamel, MJ, Msika, Albans, Kayan, Kingsley, Leboulleux, D, Alonso, Pedro, Kamthunzi, Portia, Marsh, K, Otieno, Allan, Kerubo, C, Ballou, W Ripley, Nekoye, Otsyula, Lanaspa, M, Shubis, K, Lievens, Marc, Sykes, A, Abossolo, Béatrice Peggy, Lapierre, D, Mandjate, Sofia, Chome, N, Ofori-Anyinam, O, Dosoo, D, Martinson, F, Marsh, Kevin, Urassa, Alwisa Martin, Mahende, Coline, Abdulla, S, Tsofa, B, Ali, AM, Boahen, O, Bassat, Q, Bawa, John, Sandrine, Yara, Osei-Kwakye, K, Peshu, N, Akoo, Pauline, Adjei, Samuel, Njuguna, Patricia, Jumbe, Allan, Williamson, John, Agbenyega, T, Sacarlal, J, Mtoro, A, Leboulleux, Didier, Greenwood, Brian, Malabeja, Anangisye, Wasuna, R, Chilengi, Roma, Schellenberg, D, Nhamuave, Arlindo, Guiguemdé, Robert Tinga, Awino, N, Tinto, Halidou, Tahita, Marc Christian, Mandjate, S, Asante, I, Martinson, Francis, Abossolo, BP, Tanner, M, Williamson, J, Kariuki, S, Machera, F, Kilavo, Hassan, Jones, D, Lusingu, John, Boateng, Harry Owusu, Chintedza, Joseph, Soulanoudjingar, Solange Solmeheim, Lang, Trudie, Sacarlal, Jahit, Gesase, S, Mahende, C, Ouédraogo, S, Bruls, Myriam, Guerra, Y, Msika, A, Soulanoudjingar, SS, Loucq, C, The RTS, S. Clinical Trials Partnership, Sykes, Alma, Agyekum, A, Owusu, L, Vekemans, J, Owusu, Larko, Odero, C, Tanner, Marcel, Laserson, Kayla F, Peshu, Norbert, Savarese, Barbara, Owusu-Ofori, Ruth, Omoto, J, Valea, Innocent, Chilengi, R, Bruls, M, D'Alessandro, Umberto, Onyango, AA, Hoffman, I, Salim, Nahya, Laserson, KF, D'Alessandro, U, Ballou, WR, Nkomo, R, Olotu, A +282 morecore +1 more sourceUiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši +2 morewiley +1 more sourceDesign of a phase III multicenter trial to evaluate the efficacy of the RTS,S/AS01 malaria vaccine in children across diverse transmission settings in Africa. [PDF]
, 2011 BACKGROUND\ud
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GlaxoSmithKline Biologicals and the PATH Malaria Vaccine Initiative are working in partnership to develop a malaria vaccine to protect infants and children living in malaria endemic regions of sub-Saharan Africa, which can be delivered ...Amanda Leach, Vekemans Johan, Savarese Barbara, Abdulla, Salim, Loucq, Christian, Salim Abdulla, Cahill Conor, Owusu-Agyei, Seth, Macete, Eusebio, Lievens Marc, Njuguna, Patricia, Marc Lievens, Christian Loucq, Ofori-Anyinam Opokua, Leach, Amanda, Njuguna Patricia, Vekemans, Johan, Patricia Njuguna, Cahill, Conor, Macete Eusebio, Barbara Savarese, Savarese, Barbara, Seth Owusu-Agyei, Owusu-Agyei Seth, Opokua Ofori-Anyinam, Ballou, W Ripley, Abdulla Salim, Clinical Trials Partnership Committee, Lievens, Marc, Ofori-Anyinam, Opokua, null null, Leach Amanda, Eusebio Macete, Conor Cahill, Ballou W Ripley, Loucq Christian, Johan Vekemans, W Ripley Ballou +37 morecore +1 more sourceChronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...Anu Singh, Aroonima Misra, Sufian Zaheerwiley +1 more sourceEffect Modification of Cigarette Smoking on the Relationship between Post‐traumatic Stress Disorder, Other Mental Health Conditions and Rheumatoid Arthritis Risk: A Large Case‐Control Study in U.S. Veterans
Arthritis Care &Research, Accepted Article.Objective
We examined associations of post‐traumatic stress disorder (PTSD) and other mental health disorders (OMH) with rheumatoid arthritis (RA), accounting for effects of smoking. Methods
We conducted a matched case‐control study, identifying incident RA cases and controls using national Veteran Health Administration data (2006‐2019).Kelsey Coziahr, Harlan Sayles, Tate M. Johnson, Joshua F. Baker, Punyasha Roul, Grant W. Cannon, Gary A. Kunkel, Katherine D. Wysham, Gail S. Kerr, Amir A. Razmjou, Isaac Smith, Jennifer L. Barton, Maria I. Danila, Jonathan S. Richards, Bryant R. England, Ted R. Mikuls +15 morewiley +1 more sourceA Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering
Advanced Functional Materials, EarlyView.An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa +21 morewiley +1 more sourceA narrative review of considerations when assessing potential relationships between Guillain-Barré syndrome and vaccines
Human Vaccines & ImmunotherapeuticsGuillain-Barré syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy that can result in progressive muscle weakness, paralysis, and, in severe cases, respiratory failure.Sarah Elizabeth Williams, Olympia Evdoxia Anastasiou, Maria Maddalena Lino, Caihua Liang, Joanne Wu, Cassandra Hall-Murray, Erica Chilson, Kathleen Dooling, Kyla Hayford, Elizabeth Begier +9 moredoaj +1 more source
