Results 121 to 130 of about 1,398,780 (286)

Immunostimulatory DNA Tetrahedron‐Based Nanovaccine Combined With Immune Checkpoint PD‐1 Blockade for Boosting Systemic Immune Responses Against Oral Squamous Cell Carcinoma

Aggregate, EarlyView.
This study introduces an immunomodulatory DNA tetrahedral framework nucleic acid‐based nanovaccine tFNA‐CpG. The functionalized nanovaccine shows stable and well‐defined morphological characteristics and can be efficiently taken up by APCs. When combined with the immune checkpoint inhibitor anti‐PD‐1, it notably ameliorated the immunosuppressive ...
Xueting Yang, Yun Wang, Yan Yang, Sicheng Zhang, Dianri Wang, Yi Luo, Chunyan Shui, Yongcong Cai, Ruoyi Yang, Shuang Dong, Mu Yang, Yunfeng Lin, Chao Li   +12 more
wiley   +1 more source

Development and Application of Attenuated Plant Viruses as Biological Control Agents in Japan

Viruses
In 1929, it was reported that yellowing symptoms caused by a tobacco mosaic virus (TMV) yellow mosaic isolate were suppressed in tobacco plants that were systemically infected with a TMV light green isolate.
Yasuhiro Tomitaka, Yoshifumi Shimomoto, Bo-Song Ryang, Kazusa Hayashi, Tomoka Oki, Momoko Matsuyama, Ken-Taro Sekine   +6 more
doaj   +1 more source

Effect of Pullet Vaccination on Development and Longevity of Immunity

Viruses, 2019
Avian respiratory disease causes significant economic losses in commercial poultry. Because of the need to protect long-lived poultry against respiratory tract pathogens from an early age, vaccination programs for pullets typically involve serial ...
Emily J. Aston, Brian J. Jordan, Susan M. Williams, Maricarmen García, Mark W. Jackwood   +4 more
doaj   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

Research advancements and evaluation of multifactor‐induced murine models for gastric cancer

Animal Models and Experimental Medicine, EarlyView.
Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang, Liang Zhang, Weixu Feng, Wanfeng Liu, Xiangyang Xue, Shiyu Feng   +5 more
wiley   +1 more source

New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond

Annals of Neurology, EarlyView.
The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on ...
Joseph J. Sabatino Jr., Bruce A. C. Cree, Stephen L. Hauser   +2 more
wiley   +1 more source

Embracing Complexity: Peptides as Tuneable Scaffolds in the Construction of Discrete Supramolecular Systems

Angewandte Chemie International Edition, Accepted Article.
Supramolecular chemistry has advanced rapidly, with scientists using fundamental understanding to generate function from simple building blocks. However, synthetic systems are still in their infancy when compared to biology. The increasing use of peptides in supramolecular structures provides a clear roadmap to more complex function; introducing chiral,
Ben E. Barber, Ellen M. G. Jamieson, Leah E. M. White, Charlie T. McTernan   +3 more
wiley   +1 more source

Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis

Journal of Immunology Research, 2015
Avian infectious bronchitis (IB) is a widely distributed poultry disease that has huge economic impact on poultry industry. The continuous emergence of new IBV genotypes and lack of cross protection among different IBV genotypes have been an important ...
Faruku Bande, Siti Suri Arshad, Mohd Hair Bejo, Hassan Moeini, Abdul Rahman Omar   +4 more
doaj   +1 more source

Plants, plant‐derived compounds, probiotics, and postbiotics as green agents to fight against poultry coccidiosis: A review

Animal Research and One Health, EarlyView.
Therapeutic effect of natural products on chicken coccidiosis. Abstract The intestinal tract is the main place for animals to digest food and absorb nutrients, which also serves as the first line of defense against pathogens that invade the internal environment.
Pan Chen, Kaili Liu, Taojing Yue, Yanan Lu, Senyang Li, Fuchun Jian, Shucheng Huang   +6 more
wiley   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source