Results 191 to 200 of about 122,871 (313)

Lysosome-targeting live attenuated influenza vaccines elicit robust and broad immunity in mice. [PDF]

Nat Commun
Hao J, Wang P, Shen Q, Xi X, Tong L, Hou J, Li L, Wang Q, Liu C, Li J, Zhao H, Zhang Q, Plebani R, Chou D, Zhang L, Zhou D, Si L.   +16 more
europepmc   +1 more source

Shaping expectations, losing flexibility: A study of CEO promises as strategic communication tools

Strategic Management Journal, EarlyView.
Abstract Research Summary CEO promises are powerful but understudied communication tools. We develop a dual‐mechanism framework theorizing that while CEO promises elevate stakeholder expectations, they simultaneously constrain strategic flexibility. We argue that CEO promise‐making is shaped by two competing pressures: making more promises when the ...
Majid Majzoubi, Alex Murray, William J. Mayew   +2 more
wiley   +1 more source

Preparation and Efficacy Evaluation of Heat-Resistant Freeze-Dried Live-Attenuated Vaccine Formulation of Micropterus salmoides Rhabdovirus. [PDF]

Vaccines (Basel)
Liang H, Hu G, Luo X, Lin Q, Fu X, Niu Y, Ma B, Xiao W, Cui Z, Li N.   +9 more
europepmc   +1 more source

Disc‐Toroid Hybrid Lipid Nanoparticles for Efficient Drug Encapsulation and Subcutaneous Delivery

Small, EarlyView.
This study demonstrates sub‐50 nm solid‐lipid nanoparticles with long‐term stability, high drug loading, and strong tissue compatibility. Disc‐toroid morphology is confirmed and may play a role in cellular interactions, while low cytotoxicity and minimal systemic permeation confirm depot‐like behavior. These nanoparticles represent a versatile platform
Zanelle van Niekerk, Rima Nuwayhid, Stefaniya Gaydarova, Eva Bittrich, Natalia Makarova, Susanne Boye, Christo Tzachev, Jan C. Simon, Sandra Franz, Albena Lederer   +9 more
wiley   +1 more source

Impact of general anaesthesia on immune response to first rabies vaccination in seronegative domestic cats

Veterinary Record, EarlyView.
Abstract Background Despite common concerns, evidence that anaesthesia impairs vaccine efficacy remains limited. This study assessed the impact of general anaesthesia on the immune response to rabies vaccination in cats. Methods Thirty‐five healthy female cats (6–12 months old) undergoing elective spaying were enrolled.
Pierre Bessière, Romane Breysse, Marion Chrétien, Brandon Hayes, Séverine Boullier, Anouck Labadie, Jonathan Rieder, Marine Wasniewski, Géraldine Jourdan   +8 more
wiley   +1 more source

Temperature-Dependent Viral Pathogenicity: Implications for Attenuation of Viral Vaccines. [PDF]

Viruses
Shiraki K, Kawana T, Whitley RJ.
europepmc   +1 more source

Vaccination of Cows with a Combined Rotavirus/Enterotoxigenic "E. Coli" K99 Vaccine to Protect Newborn Calves Against Diarrhoea [PDF]

, 1983
Bachmann, P. A., Baljer, G., Eichhorn, Werner, Plank, P., Schneider, P.   +4 more
core   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

The Political Economy of Patent Buyouts

The RAND Journal of Economics, EarlyView.
ABSTRACT Incentivizing innovation through buyouts may alleviate the social costs associated with patent power, but the political economy and feasibility of this potentially important financing mechanism have been understudied. We study an international setting of countries with different innovation and financing capabilities, and where financing ...
Amal Ahmad, Dominik Naeher, Sebastian Vollmer   +2 more
wiley   +1 more source

Protection Against Salmonella by Vaccination with Toxin-Antitoxin Self-Destructive Bacteria. [PDF]

Vaccines (Basel)
Gruzdev N, Pitcovski J, Katz C, Ruimi N, Eliahu D, Noach C, Rosenzweig E, Finger A, Shahar E.   +8 more
europepmc   +1 more source