Results 211 to 220 of about 1,085,685 (349)

Vaccination Against Respiratory Infections in Adults with Cancer: A Concise Guide for Clinicians. [PDF]

Vaccines (Basel)
See KC.
europepmc   +1 more source

All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery

Advanced Science, EarlyView.
Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi, Brooke E. Silverstein, Yulia Shmidov, Sonal Deshpande, Joy Tong, Yvonne Y. Ma, Chinmay S. Potnis, Soumen Saha, Xinghai Li, Max R. Ney, Sarah Y. Kim, Joshua J. Milligan, Lixin Fan, Matthew L. Becker, Daniel Reker, Ashutosh Chilkoti   +15 more
wiley   +1 more source

The lights went out.

, 2012
Cavelaars, Chen, Cholesterol Treatment Trialists' Ctt Collaboration, Kromhout, Kunitz, Leon, S. Ebrahim, Uusitalo   +7 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Compatibility and Stability of a <i>Shigella</i> Polysaccharide-Protein Conjugate Antigen Formulated with Aluminum Salt and CpG 1018^® Adjuvants. [PDF]

Vaccines (Basel)
Taskar P, Kumar P, Dotson B, Datta A, Guo S, Chalke G, Puri R, Seth H, Wizel B, Joshi SB, Volkin DB.   +10 more
europepmc   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Long-Term Impact of Pneumococcal Conjugate Vaccines on the Burden of Pneumococcal Meningitis in Mozambique, 2013-2023. [PDF]

Vaccines (Basel)
Nhantumbo AA, Weldegebriel G, de Gouveia L, Katsande R, Comé CE, Munguambe AM, Cantarelli V, Dias C, Muleia R, Sitoe EF, Zeca EV, Seni A, Tambo AN, Mussagi ACFN, Maholela PI, de Filippis I, Gudo ES.   +16 more
europepmc   +1 more source

Protein carriers of conjugate vaccines

Human Vaccines & Immunotherapeutics, 2013
M. Pichichero
semanticscholar   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Randomized Phase 3 Trial Evaluating the Safety, Tolerability, and Immunogenicity of V114, a 15-Valent PCV, Followed by PPSV23 6 Months Later (PNEU-DAY): Subgroup Analysis in Adults 18-49 Years of Age Enrolled at Center for Indigenous Health Sites. [PDF]

Vaccines (Basel)
Hammitt LL, Buchwald UK, McCauley J, Shekar T, Fu W, Cheon K, Sterling T, Tamms G, Banniettis N, Musey L, LeBlanc JJ, Weatherholtz R, Riley DP, Denny E, Tso C, Roessler K, Santosham M.   +16 more
europepmc   +1 more source