Results 261 to 270 of about 1,085,685 (349)

Multimorbidity and animal models

Animal Models and Experimental Medicine, EarlyView.
Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang, Yakun Ren, Xingjiu Yang, Mengyuan Li, Junxiu Liu, Xiaoyan Du, Wen Wang, Ran Gao   +7 more
wiley   +1 more source

Iron deficiency and vaccine efficacy: A mini-review of immunological interplay and evidence across vaccine types. [PDF]

Hum Vaccin Immunother
Mohammed J, Parveen A, Ubaid Chhapra H, Naaz Mashooq F, Shadan M.   +4 more
europepmc   +1 more source

Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights

Advanced NanoBiomed Research, EarlyView.
This review explores how surface‐coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications, emphasizing how surface chemistry governs biocompatibility, targeting, and controlled release.
Hossein Daneshgar, Sepideh Ahmadi, Nikzad Abbariki, Navid Rabiee, Sidi A. Bencherif   +4 more
wiley   +1 more source

Development of MenFive®, an affordable pentavalent meningococcal conjugate vaccine (ACYWX) for Africa and beyond. [PDF]

Hum Vaccin Immunother
Alderson MR, Regan K, Martellet L, Hosken N, Kulkarni PS, Pisal SS, LaForce FM, Dhere RM.   +7 more
europepmc   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

The Safety and Immunogenicity of a 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine (CRM197/TT) in 12-23-Month Children: A Double-Blind, Randomized, Phase III Trial in China. [PDF]

Vaccines (Basel)
Xie Z, Wang F, Huang L, Huang H, Feng G, Wang X, Tan J, Ma X, You W, Li X, Gou J, Wang Y.   +11 more
europepmc   +1 more source

Mannose‐Modified Cationic Liposome‐Based mRNA Therapeutics for Improved Triple‐Negative Breast Cancer Immunotherapy

Advanced NanoBiomed Research, EarlyView.
Schematic illustration of mTEM8‐loaded cationic liposome (cLipo‐Man/mTEM8) therapeutics for improved triple‐negative breast cancer immunotherapy. Despite triple‐negative breast cancer (TNBC) is the most heterogeneous and aggressive subtype of breast cancer, immunotherapy is emerging as a promising therapy.
Kexin Deng, Juping Sun, Junyu Liu, Yuqi Zhang, Wanwan Liu, Xiaobin Li, Han Wu, Juan Li, Jisong Zhang, Chanyuan Jin, Can Yang Zhang   +10 more
wiley   +1 more source

Higher valency vaccines' impact on antimicrobial resistance rates in <i>Streptococcus pneumoniae</i> causing invasive disease: a retrospective analysis based on national reference laboratory data, Belgium, 2018 to 2023. [PDF]

Euro Surveill
Vermeulen H, Cuypers L, Catry B, Desmet S, Hens N.   +4 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Indirect effect and pneumococcal conjugate vaccines

Педиатрическая фармакология, 2009
L. Temimi
doaj   +2 more sources