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CONJUGATED POLYSACCHARIDE VACCINES

Infectious Disease Clinics of North America, 1999
The joining of polysaccharide antigens to various proteins can result in increased immunogenicity of vaccines composed of such antigens. This article discusses conjugated polysaccharide vaccines for Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitis.
H, Ahmad, E K, Chapnick
openaire   +2 more sources

Meningococcal conjugate vaccines

Expert Opinion on Pharmacotherapy, 2004
Neisseria meningitidis is a leading cause of bacterial meningitis and sepsis in the US, Europe and in many other parts of the world, including parts of sub-Saharan Africa (known as the African 'meningitis belt'). There are > 500000 cases of meningococcal disease annually with an estimated death toll of 135000 worldwide.
Shanta M, Zimmer, David S, Stephens
openaire   +2 more sources

Pneumococcal conjugate vaccines

Immunology Letters, 1991
We have prepared conjugates of pneumococcal type 4 polysaccharides (PS4) or oligosaccharides to tetanus toxoid using the carbodiimide method. The use of a spacer, 6-aminohexanoic acid, resulted in higher incorporation of carrier protein. Conjugates contained up to 10% free polysaccharide, but no free protein.
C C, Peeters   +6 more
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Combination conjugate vaccines

Expert Opinion on Drug Safety, 2006
Increasingly, more diseases are becoming vaccine preventable, but maintaining community and provider acceptance demands that the number of injections does not increase. Combination conjugate vaccines represent an inevitable and important advance. This paper reviews the efficacy and safety of combination conjugate vaccines, including immunological ...
Naor, Bar-Zeev, Jim P, Buttery
openaire   +2 more sources

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