Results 191 to 200 of about 80,375 (245)

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, Volume 13, Issue 14, 9 March 2026.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Mono-WNV and combined WNV/TBEV inactivated vaccine efficacy against a wide range of WNV and TBEV strains. [PDF]

Front Immunol
Tuchynskaya K, Vorovitch M, Kruglov Y, Mostipanova G, Kholodilov I, Ivanova A, Kuchina V, Rogova A, Karganova G.   +8 more
europepmc   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

Safety evaluation of inactivated poliomyelitis vaccine. [PDF]

Hum Vaccin Immunother
Yan D, Yunji L, Jiawei L, Jiarong L, Junyan L, Pinyi H, Yufan Y, Jianxin Z, Zhilei Z, Jingsi Y.   +9 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Immunogenicity and efficacy of a rabies-based vaccine against highly pathogenic influenza H5N1 virus. [PDF]

Emerg Microbes Infect
Paran N, Wirblich C, Albrecht R, Zabihi-Diba L, Tarquinio A, Kurup D, Solomides CC, García-Sastre A, Schnell MJ.   +8 more
europepmc   +1 more source

An Ad5‐Based COVID‐19 Vaccine Encoding SARS‐CoV‐2 Spike Glycoprotein Induces Measurable Antibody and Cytokine Responses in Mice

Biotechnology Journal, Volume 21, Issue 3, March 2026.
Graphical Abstract and Lay Summary A recombinant adenovirus type 5–based vaccine encoding the full‐length SARS‐CoV‐2 Spike glycoprotein (Ad5Spike) was evaluated for its ability to induce cellular and humoral immune responses in BALB/c mice. Immunization with Ad5Spike resulted in the generation of antigen‐specific cellular immunity, characterized by ...
Fulya Erendor, Fatih Uzer, Salih Sanlioglu   +2 more
wiley   +1 more source

Outer membrane vesicles from <i>Aeromonas veronii</i>: biological properties and synergistic immunity enhancement with inactivated bacteria in crucian carp. [PDF]

Microbiol Spectr
Wu Z-X, An D-J, Kou Y-X, Yang Q, Zhang Z-Q, Chen L, Gao G-P, Gao G-S, Yang B-T, Kang Y-H.   +9 more
europepmc   +1 more source