Results 171 to 180 of about 1,792,624 (390)

A reflection on invasive pneumococcal disease and pneumococcal conjugate vaccination coverage in children in Southern Europe (2009–2016)

Human Vaccines & Immunotherapeutics, 2017
Higher-valent pneumococcal conjugate vaccines (PCVs) were licensed from 2009 in Europe; similar worldwide clinical effectiveness was observed for PCVs in routine use.
Marta Moreira, Olga Castro, Melissa Palmieri, Sofia Efklidou, Stefano Castagna, Bernard Hoet   +5 more
doaj   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer

Nature Communications
The prefusion conformation of human metapneumovirus fusion protein (hMPV Pre-F) is critical for eliciting the most potent neutralizing antibodies and is the preferred immunogen for an efficacious vaccine against hMPV respiratory infections.
Mark J. G. Bakkers, Tina Ritschel, Machteld Tiemessen, Jacobus Dijkman, Angelo A. Zuffianò, Xiaodi Yu, Daan van Overveld, Lam Le, Richard Voorzaat, Marlies M. van Haaren, Martijn de Man, Sem Tamara, Leslie van der Fits, Roland Zahn, Jarek Juraszek, Johannes P. M. Langedijk   +15 more
doaj   +1 more source

Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model

, 2021
Fatima Amanat, Shirin Strohmeier, Raveen Rathnasinghe, Michael Schotsaert, Lynda Coughlan, Adolfo García‐Sastre, Florian Krammer   +6 more
openalex   +1 more source

An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide

Advanced Materials, EarlyView.
Simple and inexpensive polypeptides composed of random copolymers of alanine and glutamic acid are effective antifreezes for applications in foods and biomedicine. The polypeptides, inspired by natural extremophile proteins, inhibit the growth of large ice crystals and prevent damage to sensitive biologics.
Thomas J. McPartlon, Charles T. Osborne, Ke Wang, Rachel E. Detwiler, Konrad Meister, Jessica R. Kramer   +5 more
wiley   +1 more source

Proportion of Patients in the United States Who Fill Their Nirmatrelvir/Ritonavir Prescriptions

Infectious Diseases and Therapy
Introduction Although real-world studies demonstrate that those prescribed nirmatrelvir/ritonavir (and particularly within 5 days of symptom onset) are less likely to experience severe COVID-19 outcomes, prior studies show that only a small fraction of ...
Abby E. Rudolph, Farid L. Khan, Tanya G. Singh, Srinivas Rao Valluri, Laura A. Puzniak, John M. McLaughlin   +5 more
doaj   +1 more source

To Vaccinate or Not to Vaccinate [PDF]

Infectious Diseases in Obstetrics and Gynecology, 1994
openaire   +2 more sources

mRNA vaccines — a new era in vaccinology

Nature reviews. Drug discovery, 2018
N. Pardi, Michael J. Hogan, F. Porter, D. Weissman   +3 more
semanticscholar   +1 more source

IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

Nature Immunology, 2022
S. Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh, A. Paler-Martinez, L. Kim, Sara M. Wichner, Y. Oei, Mark J. McCarron, Emily C. Freund, Zh. A. Amir, Cecile C. de la Cruz, B. Haley, C. Blanchette, J. Schartner, Weilan Ye, M. Yadav, U. Şahin, L. Delamarre, I. Mellman   +19 more
semanticscholar   +1 more source

Automated Label‐Free Assay for Viral Detection and Inhibitor Screening via Biomembrane‐Functionalized Microelectrode Arrays

Advanced Materials, EarlyView.
A bioelectronic sensor integrating 2D cell membranes with organic microelectrode arrays enables detection of SARS‐CoV‐2 fusion pathways. Natively‐expressed viral receptors promote monitoring of viral entry and screening of antibody‐based inhibitors.
Zixuan Lu, Jeremy Treiber, Konstantinos Kallitsis, Ekaterina Selivanovitch, Alexandra Wheeler, Maria Lopez‐Cavestany, Zhongmou Chao, Sarah L Barron, Ju An Park, Darius Hoven, Anna Scheeder, Aimee Withers, Becky M. Hess, Clemens F. Kaminski, Alberto Salleo, Anna‐Maria Pappa, Susan Daniel, Róisín M Owens   +17 more
wiley   +1 more source