Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He +8 more
wiley +1 more source
Investigating how sociodemographic factors and vaccination attitudes explain awareness, experience, and willingness toward COVID-19 and influenza vaccination among Taiwan residents. [PDF]
Saffari M +7 more
europepmc +1 more source
A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin +4 more
wiley +1 more source
Regulatory Strengthening as a Pillar of Health System Resilience for Sustainable Immunization. [PDF]
Tan-Koi WC, Khoo YK, Lim JC.
europepmc +1 more source
Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities
This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao +21 more
wiley +1 more source
A Chemically Induced <i>Vibrio harveyi</i> Bacterial Ghost Vaccine Confers Enhanced Protection in Turbot (<i>Scophthalmus maximus</i>). [PDF]
Lv H, Yang J, Yu R, Liu Q, Liu X.
europepmc +1 more source
Systemic inflammatory reaction after pneumococcal vaccine [PDF]
Kelley A von Elten +5 more
openalex +1 more source
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli +16 more
wiley +1 more source
Toward next-generation therapeutic HPV vaccines: A review on expanding the antigen repertoire and an integrated bioinformatics selection framework. [PDF]
Zhang D +5 more
europepmc +1 more source

