Results 251 to 260 of about 1,302,625 (339)

PRO‐LDM: A Conditional Latent Diffusion Model for Protein Sequence Design and Functional Optimization

Advanced Science, EarlyView.
PRO‐LDM is a modular latent diffusion framework that learns hierarchical biological representations to enable efficient and high‐fidelity protein design. PRO‐LDM can design species that resemble natural sequences with enhanced diversity or optimize protein functions.
Sitao Zhang, Zixuan Jiang, Rundong Huang, Wenting Huang, Siyuan Peng, Shaoxun Mo, Letao Zhu, Peiheng Li, Ziyi Zhang, Emily Pan, Xi Chen, Yunfei Long, Qi Liang, Jin Tang, Renjing Xu, Rui Qing   +15 more
wiley   +1 more source

Vaccine attitudes, practices, and literacy among New York State primary care providers and their office personnel. [PDF]

Hum Vaccin Immunother
Suryadevara M, Wang D, Domachowske J.
europepmc   +1 more source

Vaccines and vaccination strategies

Expert Review of Vaccines, 2004
openaire   +3 more sources

A Nanomodulator Enhances Radiotherapy‐Induced In Situ Cancer Vaccine by Promoting Antigen‐Presenting of Tumor‐Associated Macrophage

Advanced Science, EarlyView.
A nanomodulator (Ft‐E64/Hf@Lipo) is developed, combining radiosensitizer hafnium (Hf) and the cysteine protease inhibitor E64, which cooperatively reinvigorated the antigen presentation of TAMs. Ft‐E64/Hf@Lipo sensitized‐RT generated abundant tumor neoantigens, and then E64/antigens, along with the apoptotic tumor cells, trafficked to TAMs via ...
Xiu Zhao, Mengli Li, Jun Li, Yueying Han, Yu Gong, Zhenzhong Zhang, Jinjin Shi, Cheng‐Yun Jin, Junjie Liu, Pilei Si   +9 more
wiley   +1 more source

XBB.1.5 COVID-19 mRNA Vaccines Induce Inadequate Mucosal Immunity in Patients with Inflammatory Bowel Disease. [PDF]

Vaccines (Basel)
Woelfel S, Dütschler J, Junker D, König M, Leinenkugel G, Krieger C, Truniger S, Franke A, Koller S, Metzger-Peter K, Frei N, Star Sign Study Investigators, Albrich WC, Friedrich M, Niess JH, Schneiderhan-Marra N, Dulovic A, Korte W, Bürgi JJ, Brand S.   +19 more
europepmc   +1 more source

Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine

Advanced Science, EarlyView.
A glucose‐catalyzed chemodynamic strategy is proposed to activate therapeutic genome editing of SMARCAL1to improve cancer immunotherapy. This innovative design featuring Fenton reaction activity and glucose consumption ability, not only effectively synergizes to activate the cGAS‐STING pathway but also inhibits the opposing functions of interferon by ...
Yuwei Li, Yuanyi Zhang, Chenchen Li, Guoping Chen, Pir Muhammad, Yonghong Yao, Lifang Gao, Zhigang Liu, Yanli Wang   +8 more
wiley   +1 more source

A goatpox but not sheeppox heterologous live attenuated vaccines provide complete protection against lumpy skin disease in cattle under experimental conditions. [PDF]

Sci Rep
Haegeman A, Philips W, Mostin L, De Leeuw I, Van Campe W, Saegerman C, De Clercq K, De Regge N.   +7 more
europepmc   +1 more source

APPLICATION OF VACCINES IN PUBLIC HEALTH WORK

, 1920
GEORGE W. McCOY
openalex   +2 more sources

Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery

Advanced Science, EarlyView.
Machine Learning (ML) is revolutionizing cancer nanomedicine by optimizing nanoparticle (NP) design and drug delivery. This review summarizes ML applications across all stages of NP drug delivery, along with a discussion of ongoing challenges and future directions.
Qingquan Wang, Yujian Liu, Chenchen Li, Bin Xu, Shidang Xu, Bin Liu   +5 more
wiley   +1 more source

mRNA-LNP Vaccines Targeting SmpA-PLD and OmpK-Omp22 Induce Protective Immunity Against <i>Acinetobacter baumannii</i>. [PDF]

Vaccines (Basel)
Liu C, Wang X, Zheng Y, Gao X, Jin J, Cheng X, He Y, Wang PG.   +7 more
europepmc   +1 more source