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COVID-19 vaccines: modes of immune activation and future challenges
Nature reviews. Immunology, 2021 The new vaccines against SARS-CoV-2 are novel in terms of specificity, their wide dissemination across the global population and the inclusion of newly licensed mRNA platforms.
J. Teijaro, D. Farber
semanticscholar +1 more source
COVID-19 vaccines: where we stand and challenges ahead
Cell Death and Differentiation, 2021 In the eleven months elapsed since the identification of the SARS-CoV-2 virus and its genome, an exceptional effort by the scientific community has led to the development of over 300 vaccine projects.
Guido Forni +26 more
semanticscholar +1 more source
npj Vaccines, 2022 The adenovirus (Ad)26 serotype–based vector vaccine Ad26.COV2.S has been used in millions of subjects for the prevention of COVID-19, but potentially elicits persistent anti-vector immunity.
Selina Khan +7 more
doaj +1 more source
Cervical Cancer-Associated Human Papillomavirus 16 E7 Oncoprotein Inhibits Induction of Anti-Cancer Immunity by a CD4+ T Cell Dependent Mechanism [PDF]
, 2009 Attempts to develop therapeutic vaccines against cervical cancer have been proven difficult. One of the major causes of the failure is due to the use of the wrong mouse models based on transplantable tumours in testing the efficacy of vaccines.
Germain J. Fernando +3 more
core +2 more sources
Human papillomavirus and HPV vaccines: a review [PDF]
, 2007 Cervical cancer, the most common cancer affecting women in developing countries, is caused by persistent infection with "high-risk" genotypes of human papillomaviruses (HPV). The most common oncogenic HPV genotypes are 16 and 18, causing approximately 70%
Castellsague, X. +10 more
core +3 more sources
Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability
npj Vaccines, 2023 During the COVID-19 pandemic, Pfizer-BioNTech and Moderna successfully developed nucleoside-modified mRNA lipid nanoparticle (LNP) vaccines. SARS-CoV-2 spike protein expressed by those vaccines are identical in amino acid sequence, but several key ...
Lizhou Zhang +9 more
semanticscholar +1 more source
, 2009 Vaccine research, as well as the development, testing, clinical trials, and commercial uses of vaccines involve complex processes with various biological data that include gene and protein expression, analysis of molecular and cellular interactions ...
Alan Ruttenberg +20 more
core +3 more sources
Advanced Drug Delivery Reviews, 2021 mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology, and nanotechnology have generated interest in delivering safe and effective mRNA ...
Jeonghwan Kim +3 more
semanticscholar +1 more source
Malaria vaccines 1985-2005: a full circle?
, 2005 Few who were actively engaged in malaria vaccine research 20 years ago (including myself) would have imagined that, in 2005, there would still be a prediction of a 10-20-year horizon before vaccines become part of malaria-control strategies.
Targett, Geoffrey A
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mRNA vaccines manufacturing: Challenges and bottlenecks
Vaccine, 2021 Vaccines are one of the most important tools in public health and play an important role in infectious diseases control. Owing to its precision, safe profile and flexible manufacturing, mRNA vaccines are reaching the stoplight as a new alternative to ...
S. S. Rosa +3 more
semanticscholar +1 more source