Results 61 to 70 of about 1,591,431 (356)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A phase I, randomized, controlled, dose-ranging study of investigational acellular pertussis (aP) and reduced tetanus-diphtheria-acellular pertussis (TdaP) booster vaccines in adults

Human Vaccines & Immunotherapeutics, 2018
Despite high vaccination coverage worldwide, pertussis has re-emerged in many countries. This randomized, controlled, observer-blind phase I study and extension study in Belgium (March 2012–June 2015) assessed safety and immunogenicity of investigational
Geert Leroux-Roels, Maria Lattanzi, Claudia Dovali Solis, Mario Contorni, Marco Costantini, Luca Moraschini, Monia Bardelli, Sylvie Bertholet, Erica Borgogni, Francesca Buricchi, Rocco Cantisani, Elisa Faenzi, Oretta Finco, Rosanna Leuzzi, Mariagrazia Pizza, Domenico Rosa, Francesca Schiavetti, Anja Seubert, Fabiana Spensieri, Gianfranco Volpini, Luisanna Zedda, Giuseppe Del Giudice, Ilaria Galgani   +22 more
doaj   +1 more source

Protein Antigens Increase the Protective Efficacy of a Capsule-Based Vaccine against Staphylococcus aureus in a Rat Model of Osteomyelitis [PDF]

, 2014
Staphylococcus aureus is an invasive bacterial pathogen, and antibiotic resistance has impeded adequate control of infections caused by this microbe. Moreover, efforts to prevent human infections with single-component S. aureus vaccines have failed.
Buzzola, Fernanda Roxana, Denoël, Philippe, Germain, Sophie, Lattar, Santiago Martín, Lee, Jean C., Noto Llana, Mariangeles, Sordelli, Daniel Oscar   +6 more
core   +2 more sources

The dawn of mRNA vaccines: The COVID-19 case

Journal of Controlled Release, 2021
In less than one year since the outbreak of the COVID-19 pandemic, two mRNA-based vaccines, BNT162b2 and mRNA-1273, were granted the first historic authorization for emergency use, while another mRNA vaccine, CVnCoV, progressed to phase 3 clinical ...
Rein Verbeke, I. Lentacker, S. D. De Smedt, H. Dewitte   +3 more
semanticscholar   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Comparative Effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & Johnson) Vaccines in Preventing COVID-19 Hospitalizations Among Adults Without Immunocompromising Conditions — United States, March–August 2021

MMWR. Morbidity and mortality weekly report, 2021
Three COVID-19 vaccines are authorized or approved for use among adults in the United States (1,2). Two 2-dose mRNA vaccines, mRNA-1273 from Moderna and BNT162b2 from Pfizer-BioNTech, received Emergency Use Authorization (EUA) by the Food and Drug ...
W. Self, M. Tenforde, J. Rhoads, M. Gaglani, A. Ginde, D. Douin, Samantha M. Olson, H. Talbot, J. Casey, N. Mohr, A. Zepeski, T. McNeal, S. Ghamande, K. Gibbs, D. Files, D. Hager, A. Shehu, M. Prekker, H. Erickson, M. Gong, A. Mohamed, D. Henning, J. Steingrub, I. Peltan, Samuel M. Brown, E. Martin, A. Monto, Akram Khan, C. Hough, L. Busse, C. T. ten Lohuis, A. Duggal, Jennifer G. Wilson, A. Gordon, N. Qadir, Steven Y. Chang, C. Mallow, C. Rivas, H. Babcock, Jennie H. Kwon, M. Exline, N. Halasa, J. Chappell, A. Lauring, Carlos G. Grijalva, T. Rice, I. D. Jones, William B. Stubblefield, A. Baughman, K. Womack, C. Lindsell, K. Hart, Yuwei Zhu, Lisa Mills, Sandra N. Lester, M. Stumpf, Eric A. Naioti, Miwako Kobayashi, J. Verani, N. Thornburg, Manish M. Patel, Nicole Calhoun, Kempapura Murthy, Judy Herrick, A. McKillop, E. Hoffman, Martha Zayed, Michael E. Smith, Natalie Seattle, J. Ettlinger, E. Priest, Jennifer Thomas, A. Arroliga, M. Beeram, R. Kindle, Lori-Ann Kozikowski, Lesley De Souza, Scott Ouellette, Sherell Thornton-Thompson, Omar Mehkri, K. Ashok, Susan Gole, Alexander King, Bryan Poynter, Nicholas Stanley, Audrey Hendrickson, Ellen Maruggi, Tyler Scharber, J. Jorgensen, R. Bowers, J. King, V. Aston, Brent P. Armbruster, R. Rothman, Rahul R. Nair, J. Chen, S. Karow, E. Robart, P. Maldonado, Maryiam Khan, Preston So, Joel D. Levitt, Cynthia Perez, A. Visweswaran, J. Roque, Adreanne Rivera, L. Angeles, Trevor Frankel, Jennifer Goff, D. Huynh, Michelle P Howell, Jennifer Friedel, Michael Tozier, C. Driver, Michael Carricato, Alexandra E Foster, Paul Nassar, Laura Stout, Zita A. Sibenaller, Alicia Walter, J. Marés, Logan Olson, Bradley Clinansmith, C. Rivas, H. Gershengorn, E. McSpadden, R. Truscon, A. Kaniclides, Lara J. Thomas, Ramsay Bielak, W. Valvano, Rebecca Fong, W. Fitzsimmons, C. Blair, A. Valesano, Julie Gilbert, Christine D. Crider, Kyle A. Steinbock, Thomas C. Paulson, Layla A. Anderson, Christina Kampe, Jake Johnson, Rendie Mchenry, Marcia A. Blair, D. Conway, M. LaRose, Leigha D. Landreth, Madeline Hicks, L. Parks, Jahnavi Bongu, David W. Mcdonald, Candice Cass, Sondra M. Seiler, David Park, T. Hink, Meghan A. Wallace, C. Burnham, Olivia G. Arter   +157 more
semanticscholar   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Enhanced Systemic Humoral Immune Response Induced in Mice by Generalized Modules for Membrane Antigens (GMMA) Is Associated with Affinity Maturation and Isotype Switching

Vaccines, 2023
Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived from Gram-negative bacteria that can be used to design affordable subunit vaccines. GMMA have been observed to induce a potent humoral immune response in preclinical and
Diego Piccioli, Francesca Buricchi, Marta Bacconi, Nicoletta Bechi, Barbara Galli, Francesca Ferlicca, Enrico Luzzi, Elena Cartocci, Sara Marchi, Giacomo Romagnoli, Renzo Alfini, Roberta Di Benedetto, Simona Gallorini, Silvana Savino, Brunella Brunelli, Erika Bartolini, Francesca Micoli   +16 more
doaj   +1 more source

SARS-CoV-2 Vaccines: Status Report

Immunity, 2020
SARS-CoV-2, the causal agent of COVID-19, first emerged in late 2019 in China. It has since infected more than 870,000 individuals and caused more than 43,000 deaths globally.
F. Amanat, F. Krammer
semanticscholar   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source