Results 61 to 70 of about 714,773 (317)
npj Vaccines, 2022 Without clinical efficacy data, vaccine protective effect may be extrapolated from animals to humans using an immunologic marker that correlates with protection in animals. This immunobridging approach was used for the two-dose Ebola vaccine regimen Ad26.
Viki Bockstal +17 more
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionIn the absence of clinical efficacy data, vaccine protective effect can be extrapolated from animals to humans, using an immunological biomarker in humans that correlates with protection in animals, in a statistical approach called ...
Chelsea McLean +19 more
doaj +1 more source
Detecting Anti-Vaccine Users on Twitter [PDF]
arXiv, 2021 Vaccine hesitancy, which has recently been driven by online narratives, significantly degrades the efficacy of vaccination strategies, such as those for COVID-19. Despite broad agreement in the medical community about the safety and efficacy of available vaccines, a large number of social media users continue to be inundated with false information ...
arxiv
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
The Information Ecosystem of Online Groups with Anti- and Pro-vaccine Views on Facebook [PDF]
arXiv, 2021 Opposition and hesitancy to vaccination have been one of the major threats to global health. Social media sites have been suspected as a breeding ground of misleading narratives about vaccines, but little is known about how pervasive anti-vaccine views are on the world's largest social media, Facebook.
arxiv
FEBS Open Bio, EarlyView.ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu +6 more
wiley +1 more source
Vaccination strategies and transmission of COVID-19: evidence across advanced countries [PDF]
arXiv, 2021 Given limited supply of approved vaccines and constrained medical resources, design of a vaccination strategy to control a pandemic is an economic problem. We use time-series and panel methods with real-world country-level data to estimate effects on COVID-19 cases and deaths of two key elements of mass vaccination - time between doses and vaccine type.
arxiv
Protein O‐glycosylation in the Bacteroidota phylum
FEBS Open Bio, EarlyView.Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns +2 more
wiley +1 more source
Mechanism of action of mRNA-based vaccines
Expert Review of Vaccines, 2017 Introduction: The present review summarizes the growing body of work defining the mechanisms of action of this exciting new vaccine technology that should allow rational approaches in the design of next generation mRNA vaccines.
Carlo Iavarone +4 more
doaj +1 more source
Vaccination dilemma on an evolving social network [PDF]
arXiv, 2019 Vaccination is crucial for the control of epidemics. Yet it is a social dilemma since non-vaccinators can benefit from the herd immunity created by the vaccinators. Thus the optimum vaccination level is not reached via voluntary vaccination at times.
arxiv