Results 61 to 70 of about 1,772,507 (392)

Vaccines, Vaccination, and Vaccinology [PDF]

The Journal of Infectious Diseases, 2003
Although the demonstration in 1796 by Edward Jenner that vaccinia virus could protect against smallpox was epochal, he was following the path opened by the ancients who had used the smallpox virus itself in the practice of variolation. The work of Louis Pasteur on chicken cholera opened the way to vaccine development in the laboratory.
openaire   +3 more sources

Enhanced Systemic Humoral Immune Response Induced in Mice by Generalized Modules for Membrane Antigens (GMMA) Is Associated with Affinity Maturation and Isotype Switching

Vaccines, 2023
Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived from Gram-negative bacteria that can be used to design affordable subunit vaccines. GMMA have been observed to induce a potent humoral immune response in preclinical and
Diego Piccioli, Francesca Buricchi, Marta Bacconi, Nicoletta Bechi, Barbara Galli, Francesca Ferlicca, Enrico Luzzi, Elena Cartocci, Sara Marchi, Giacomo Romagnoli, Renzo Alfini, Roberta Di Benedetto, Simona Gallorini, Silvana Savino, Brunella Brunelli, Erika Bartolini, Francesca Micoli   +16 more
doaj   +1 more source

The role of vaccines in combatting antimicrobial resistance

Nature Reviews Microbiology, 2021
The use of antibiotics has enabled the successful treatment of bacterial infections, saving the lives and improving the health of many patients worldwide.
F. Micoli, F. Bagnoli, R. Rappuoli, D. Serruto   +3 more
semanticscholar   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

LytM Proteins Play a Crucial Role in Cell Separation, Outer Membrane Composition, and Pathogenesis in Nontypeable Haemophilus influenzae

mBio, 2015
LytM proteins belong to a family of bacterial metalloproteases. In Gram-negative bacteria, LytM factors are mainly reported to have a direct effect on cell division by influencing cleavage and remodeling of peptidoglycan.
Giuseppe Ercoli, Chiara Tani, Alfredo Pezzicoli, Irene Vacca, Manuele Martinelli, Simone Pecetta, Roberto Petracca, Rino Rappuoli, Mariagrazia Pizza, Nathalie Norais, Marco Soriani, Beatrice Aricò   +11 more
doaj   +1 more source

Attitudes towards vaccines and intention to vaccinate against COVID-19: Implications for public health communications in Australia

medRxiv, 2021
Objective: To examine SARS-CoV-2 vaccine confidence, attitudes and intentions in Australian adults. Methods: Nationwide survey in February-March 2021 of adults representative across sex, age and location. Vaccine uptake and a range of putative drivers of
J. Enticott, Jaskirat Gill, Simon L Bacon, Kim Lavoie, D. Epstein, S. Dawadi, H. Teede, J. Boyle   +7 more
semanticscholar   +1 more source

Schmallenberg Virus: To Vaccinate, or Not to Vaccinate? [PDF]

Vaccines, 2020
Schmallenberg virus (SBV), a teratogenic orthobunyavirus that infects predominantly ruminants, emerged in 2011 in Central Europe, spread rapidly throughout the continent, and subsequently established an endemic status with re-circulations to a larger extent every 2 to 3 years.
Kerstin Wernike, Martin Beer
openaire   +4 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A phase I, randomized, controlled, dose-ranging study of investigational acellular pertussis (aP) and reduced tetanus-diphtheria-acellular pertussis (TdaP) booster vaccines in adults

Human Vaccines & Immunotherapeutics, 2018
Despite high vaccination coverage worldwide, pertussis has re-emerged in many countries. This randomized, controlled, observer-blind phase I study and extension study in Belgium (March 2012–June 2015) assessed safety and immunogenicity of investigational
Geert Leroux-Roels, Maria Lattanzi, Claudia Dovali Solis, Mario Contorni, Marco Costantini, Luca Moraschini, Monia Bardelli, Sylvie Bertholet, Erica Borgogni, Francesca Buricchi, Rocco Cantisani, Elisa Faenzi, Oretta Finco, Rosanna Leuzzi, Mariagrazia Pizza, Domenico Rosa, Francesca Schiavetti, Anja Seubert, Fabiana Spensieri, Gianfranco Volpini, Luisanna Zedda, Giuseppe Del Giudice, Ilaria Galgani   +22 more
doaj   +1 more source

COVID-19 vaccines: rapid development, implications, challenges and future prospects

Human Cell, 2021
COVID-19 has affected millions of people and put an unparalleled burden on healthcare systems as well as economies throughout the world. Currently, there is no decisive therapy for COVID-19 or related complications.
Shivaji B. Kashte, A. Gulbake, S. F. El-Amin III, Ashim Gupta   +3 more
semanticscholar   +1 more source