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Metabolic reprogramming tips vaccinia virus infection outcomes by stabilizing interferon-γ induced IRF1. [PDF]
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Annual Review of Microbiology, 2003
▪ Abstract Vaccinia virus (VV), the virus smallpox vaccine, replicates in the cytoplasm of infected cells. The intracellular movement of this large virus would be inefficient without specific transport mechanisms; therefore, VV uses microtubules for movement during both entry and egress.
Geoffrey L, Smith +2 more
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▪ Abstract Vaccinia virus (VV), the virus smallpox vaccine, replicates in the cytoplasm of infected cells. The intracellular movement of this large virus would be inefficient without specific transport mechanisms; therefore, VV uses microtubules for movement during both entry and egress.
Geoffrey L, Smith +2 more
openaire +2 more sources
Archives of Virology, 1977
Extracts of vaccinia-infected HeLa cells were rendered free from infectious virus by centrifugation followed by membrane filtration and were shown to be toxic to uninfected HeLa cells in the presence of hypertonic MgSO4, used as a macromolecular uptake inducer, under conditions which did not kill control cells.
J, Wolstenholme +3 more
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Extracts of vaccinia-infected HeLa cells were rendered free from infectious virus by centrifugation followed by membrane filtration and were shown to be toxic to uninfected HeLa cells in the presence of hypertonic MgSO4, used as a macromolecular uptake inducer, under conditions which did not kill control cells.
J, Wolstenholme +3 more
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Vaccinia Virus Expression Vectors
Annual Review of Immunology, 1987Infectious diseases remain a major problem throughout the world. It is clear, at least for viruses, that prevention is our best defense. Most successful vaccines (e.g., smallpox, rubella, Sabin poliomyelitis, measles, mumps, yellow fever) have consisted of live attenuated viruses.
B, Moss, C, Flexner
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Immunological Reviews, 1997
SummaryVaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include proteins which oppose apoptosis. Synthesise steroids, capture chemokines, counteract complement, interfere with interferon and intercept ...
G L, Smith +4 more
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SummaryVaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include proteins which oppose apoptosis. Synthesise steroids, capture chemokines, counteract complement, interfere with interferon and intercept ...
G L, Smith +4 more
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Vaccinia Virus Expression Vectors
Journal of General Virology, 1986Introduction. Recombinant DNA technology has made possible the expression of heterologous genes in a variety of animal viruses (for review, see Rigby, 1983). The availability of a wide variety of animal virus vectors enables a foreign gene to be expressed in different cell types, at different levels and with different consequences for the host cell ...
M, Mackett, G L, Smith
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Nature, 1974
Extracts of vaccinia-infected HeLa cells were rendered free from infectious virus by centrifugation followed by membrane filtration and were shown to be toxic to uninfected HeLa cells in the presence of hypertonic MgSO4, used as a macromolecular uptake inducer, under conditions which did not kill control cells.
J, Stephen +3 more
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Extracts of vaccinia-infected HeLa cells were rendered free from infectious virus by centrifugation followed by membrane filtration and were shown to be toxic to uninfected HeLa cells in the presence of hypertonic MgSO4, used as a macromolecular uptake inducer, under conditions which did not kill control cells.
J, Stephen +3 more
openaire +2 more sources