Results 31 to 40 of about 2,277 (122)

The Yeast Vacuolar Proton-translocating ATPase Contains a Subunit Homologous to the Manduca sexta and Bovine e Subunits That Is Essential for Function [PDF]

open access: yesJournal of Biological Chemistry, 2004
The yeast cwh36Delta mutant was identified in a screen for yeast mutants exhibiting a Vma(-) phenotype suggestive of loss of vacuolar proton-translocating ATPase (V-ATPase) activity. The mutation disrupts two genes, CWH36 and a recently identified open reading frame on the opposite strand, YCL005W-A.
Maria, Sambade, Patricia M, Kane
openaire   +2 more sources

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

open access: yesExperimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie   +3 more
wiley   +1 more source

Salt glands in exo‐recretohalophytes: Development, physiological functions, and prospects for improving crop salt tolerance

open access: yesJournal of Integrative Plant Biology, Volume 68, Issue 8, Page 2368-2387, August 2026.
This review examines salt glands in exo‐recretohalophytes, in which epidermal stem cells differentiate into unicellular, bicellular, or multicellular salt glands. Salt ions are transported to the leaves via the transpiration stream and enter salt glands through symplastic and apoplastic pathways. Finally, salt glands actively secrete salt ions from the
Limin Wang   +11 more
wiley   +1 more source

The multidimensional regulation roles and mechanisms of calcium in fruit quality

open access: yesJournal of Integrative Plant Biology, Volume 68, Issue 8, Page 2747-2767, August 2026.
This review explores how calcium signaling molecule integrates plant hormones, environmental cues, and developmental signals to influence external fruit traits, internal nutritional properties, and physiological disorders. ABSTRACT Calcium (Ca2+), a dual‐functional mineral that serves both as an essential structural factor and a signaling molecule ...
Fei Jiang   +6 more
wiley   +1 more source

14‐3‐3 proteins: Central hubs in plant development and stress adaptation

open access: yesJournal of Integrative Plant Biology, Volume 68, Issue 8, Page 3107-3132, August 2026.
This review highlights recent advances elucidating the important roles of 14‐3‐3 proteins in regulating phytohormone networks, biotic and abiotic stress tolerance, growth‐defense trade‐offs, and evolutionary adaptations. Furthermore, it provides a forward‐looking perspective on 14‐3‐3 biology and the development of climate‐resilient smart crops under ...
Jiale Yuan   +6 more
wiley   +1 more source

Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives

open access: yesMedComm, Volume 7, Issue 7, July 2026.
Schematic illustration of four emerging CRISPR–Cas delivery platforms defined by distinct design principles and structural features: virus‐mimicking nanosystems (e.g., VLPs), cell‐derived extracellular vesicles, cell‐penetrating peptides, and stimuli‐responsive scaffolds. These platforms enable spatiotemporally controlled delivery of RNPs, mRNA, or DNA
Meijia Yang   +9 more
wiley   +1 more source

RNA interference in crop protection: opportunities and challenges during the transition to commercialization

open access: yesPest Management Science, Volume 82, Issue 7, Page 5971-5986, July 2026.
RNA interference (RNAi) technologies, host‐induced gene silencing (HIGS) and spray‐induced gene silencing (SIGS), potentially offer sustainable crop protection. However, efficacy, costs, regulatory clarity, and socio‐environmental impacts require further evaluation for broader use.
Elisabetta Sergi   +12 more
wiley   +1 more source

Nucleotide Labeling and Reconstitution of the Recombinant 58-kDa Subunit of the Vacuolar Proton-translocating ATPase

open access: yesJournal of Biological Chemistry, 1995
Evidence suggests that ATP hydrolysis catalyzed by the clathrin-coated vesicle proton-translocating ATPase requires at least four polypeptides of molecular masses of 70, 58, 40, and 33 kDa (Xie, X.-S., and Stone, D.K. (1988) J. Biol. Chem. 263, 9859-9867).
openaire   +2 more sources

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

open access: yesAdvanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang   +9 more
wiley   +1 more source
vacuoles
proton-translocating atpases
saccharomyces cerevisiae
molecular sequence data
animals
amino acid sequence
base sequence
protons
hydrogen-ion concentration
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