Results 41 to 50 of about 2,277 (122)

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Gene‐specific double‐stranded RNAs induce mortality in the South African mealybug Delottococcus aberiae

Pest Management Science, Volume 82, Issue 6, Page 5184-5194, June 2026.
Gene‐specific double‐stranded RNAs effectively silence essential genes in the invasive citrus pest Delottococcus aberiae, leading to significant mortality through both microinjection and oral delivery. These results provide proof of concept for RNA interference‐based biopesticides as selective and sustainable tools for citrus integrated pest management.
Carolina Gallego‐Giraldo, Alberto Urbaneja, Omar Ruíz‐Rivero, Verónica Aragonés, Marie Guijarro‐Guijarro, José‐Antonio Daròs, Meritxell Perez‐Hedo   +6 more
wiley   +1 more source

Sphingosine‐1‐Phosphate Promotes FOS Activation in Osteosarcoma Under Tumor Acidosis

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The tumor microenvironment in solid tumors is characterized by extracellular acidosis, which promotes cancer aggressiveness. In osteosarcoma, the most common primary bone cancer, a highly acidic tumor microenvironment is associated with metastasis and poor prognosis, partly due to metabolic rewiring, including changes in lipid pathways ...
Nicolò Bozzini, Margherita Cortini, Alberto Righi, Agamemnon E. Grigoriadis, Michael Dack, Elizabeta Ilieva, Federica Torricelli, Veronica Manicardi, Nicola Baldini, Sofia Avnet   +9 more
wiley   +1 more source

Chromaffin Versus Platelet Granules: What We Have Learned From Chromaffin Cells for Human Studies

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Chromaffin cells and platelets both utilize exocytosis to release biogenic amines stored within large dense‐core vesicles—specifically chromaffin granules (epinephrine) and δ‐granules (serotonin). While the chromaffin cell is the foundational model for studying the secretory pathway, platelets offer a highly accessible human cell source for clinical ...
Ricardo Borges
wiley   +1 more source

Proteomic changes during boron tolerance in barley(Hordeum vulgare) and the role of vacuolar proton-translocating ATPase subunit E

Turkish Journal of Botany, 2011
Boron is an essential micronutrient for plants and animals; however, it can be toxic when present at high concentrations. The purpose of this study was to understand the mechanisms of boron tolerance in the Turkish barley (Hordeum vulgare) Anadolu cultivar.
Atik, Ahmet Emin, Bozdağ, Gönensin Ozan, Akıncı, Ersin, Kaya, Alaattin, Koç, Ahmet, Yalçın, Talat, Karakaya, Hüseyin Çağlar   +6 more
openaire   +2 more sources

Involvement of the vacuolar proton-translocating ATPase in multiple steps of the endo-lysosomal system and in the contractile vacuole system of Dictyostelium discoideum

Journal of Cell Science, 1996
ABSTRACT We have investigated the effects of Concanamycin A (CMA), a specific inhibitor of vacuolar type H+-ATPases, on acidification and function of the endo-lysosomal and contractile vacuole (CV) systems of D. discoideum. This drug inhibited acidification and increased the pH of endo-lysosomal vesicles both in vivo and in vitro in a ...
Temesvari, Lesly A., Rodriguez-Paris, Juan M., Bush, John M., Zhang, Linyi, Cardelli, James A.   +4 more
openaire   +3 more sources

Vacuolar Proton-Translocating ATPase May Take Part in the Drug Resistance Phenotype of Glioma Stem Cells

International Journal of Molecular Sciences
The vacuolar proton-translocating ATPase (V-ATPase) is a transmembrane multi-protein complex fundamental in maintaining a normal intracellular pH. In the tumoral contest, its role is crucial since the metabolism underlying carcinogenesis is mainly based on anaerobic glycolytic reactions.
Martina Giambra, Andrea Di Cristofori, Francesca Raimondo, Roberta Rigolio, Donatella Conconi, Gaia Chiarello, Silvia Maria Tabano, Laura Antolini, Gabriella Nicolini, Miriam Bua, Davide Ferlito, Giorgio Carrabba, Carlo Giorgio Giussani, Marialuisa Lavitrano, Angela Bentivegna   +14 more
openaire   +2 more sources

Identification of a domain in the V0 subunit d that is critical for coupling of the yeast vacuolar proton-translocating ATPase.

The Journal of biological chemistry, 2006
Vacuolar proton-translocating ATPase pumps consist of two domains, V(1) and V(o). Subunit d is a component of V(o) located in a central stalk that rotates during catalysis. By generating mutations, we showed that subunit d couples ATP hydrolysis and proton transport.
Margaret A, Owegi, Donald L, Pappas, Mark W, Finch, Sarah A, Bilbo, Cruz A, Resendiz, Lori J, Jacquemin, Aswathy, Warrier, John D, Trombley, Kathryn M, McCulloch, Katrina L M, Margalef, Melissa J, Mertz, Jason M, Storms, Craig A, Damin, Karlett J, Parra   +13 more
openaire   +1 more source

Vacuolar proton-translocating ATPase is required for antifungal resistance and virulence of Candida glabrata

Vacuolar proton-translocating ATPase is required for antifungal resistance and virulence of Candida glabrata
Vacuolar proton-translocating ATPase (V-ATPase) is located in fungal vacuolar membranes.It is involved in multiple cellular processes, including the maintenance of intracellular ion homeostasis by maintaining acidic pH within the cell. The importance of V-ATPase in virulence has been demonstrated in several pathogenic fungi, including Candida albicans.
openaire   +1 more source

A self-sensing vacuole/lysosome: V-ATPase dysfunction activates selective autophagy. [PDF]

Autophagy
Huang Y, Klionsky DJ.
europepmc   +1 more source