Results 161 to 170 of about 395,932 (267)

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Quantitative three-dimensional imaging of <i>Coxiella burnetii</i> infection by focused ion beam-scanning electron microscopy. [PDF]

Infect Immun
Botting JM, Steiner S, Graham M, Liu X, Roy CR, Liu J.   +5 more
europepmc   +1 more source

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

The Tonoplast Topology Index-a new metric for describing vacuole organization. [PDF]

Plant Methods
Kočová H, Caldarescu GA, Bezvoda R, Cvrčková F.   +3 more
europepmc   +1 more source

Anatomy and Histology of the Midgut of Atopozelus opsimus (Heteroptera: Reduviidae)

Acta Zoologica, EarlyView.
ABSTRACT Atopozelus opsimus Elkins, 1954 (Heteroptera: Reduviidae) preys on forest and agricultural pests but also feeds on extrafloral nectar; however, its alimentary canal is poorly understood. The aim was to describe the anatomy and histology of the A. opsimus midgut. The alimentary canal of female and male A.
Bruna Silva Lisboa, José Eduardo Serrão, Jamile Fernanda Silva Cossolin, Germano Leão Demolin Leite, José Cola Zanuncio, Sebastião Lourenço de Assis Júnior, Pedro Guilherme Lemes   +6 more
wiley   +1 more source

Dense granule proteins: key mediators of <i>Toxoplasma gondii</i> pathogenesis and therapeutic targets. [PDF]

Front Med (Lausanne)
Zeng R, Bacha H, Zaman SU, Abohashrh M, Alonaizan R, Alzahrani KJ, Alsharif KF, Alzahrani FM, Qadeer A, Fu Q.   +9 more
europepmc   +1 more source

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source

Recycling of Vps68 depends on retromer and Mvp1/SNX8. [PDF]

Biol Open
Kölling R.
europepmc   +1 more source

A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8

Brain Pathology, EarlyView.
We describe a novel adult‐onset myopathy with autophagic vacuoles and characteristic features of ceroid lipofuscinosis associated with biallelic CLN8 variants, seizures, and muscle weakness. Autophagosomal/lysosomal deposition of curvilinear, autofluorescent material containing the mitochondrial adenosine triphosphate (ATP) synthase membrane subunit c ...
Ulrika Lindgren, Carola Hedberg‐Oldfors, Kittichate Visuttijai, Sara Nordström, Hans Goebel, Anders Oldfors   +5 more
wiley   +1 more source

Transient pH changes drive vacuole formation in enzyme-polymer condensates. [PDF]

Nat Chem Eng
Modi N, Nimiwal R, Liao J, Li Y, Bishop KJM, Obermeyer AC.   +5 more
europepmc   +1 more source