Results 91 to 100 of about 100,485 (295)

Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

open access: yesAdvanced Science, EarlyView.
Diagram of the reprogramming of FA metabolism mediated by LDHC4‐induced ACAA2 activity to promote TNBC progression. LDHC4 drives TNBC progression by enhancing ACAA2‐mediated fatty acid production. The resulting accumulation of FFAs stimulates autophagy and accelerates cell cycle progression, thereby promoting tumor growth.
Zhaolei Cui   +10 more
wiley   +1 more source

Nortriptyline Inhibits Lysosomal Exocytosis‐Mediated SASP During Gastric Cancer Progression via Targeting HOXA1‐PITX2 Phase Separation

open access: yesAdvanced Science, EarlyView.
This study identifies that HOXA1 facilitates transcriptional activity of PITX2 in liquid condensates, resulting in up‐regulation of MCOLN1 and RAB3A followed by lysosomal exocytosis of LGALS1 and IGFBP7 from senescent cells, thus activating AKT signaling and EMT.
Yi Zhou   +10 more
wiley   +1 more source

Loss‐Based Ensemble Generative Adversarial Network Model for Enhancing the Sperm Morphology Classification

open access: yesAdvanced Intelligent Systems, EarlyView.
A loss‐based ensemble generative adversarial network (GAN) framework is proposed to address mode collapse in sperm morphology classification. By integrating spatial augmentation and multiple GAN models, the study enhances synthetic data quality. The Shifted Window Transformer achieves 95.37% accuracy on the HuSHeM dataset, outperforming previous ...
Berke Cansiz   +2 more
wiley   +1 more source

Vacuolating Agent [PDF]

open access: yesBMJ, 1961
D I, MAGRATH, K, RUSSELL, J O, TOBIN
openaire   +2 more sources

Stacked scattering: The key to bright flowers lies in the mesophyll

open access: yesAmerican Journal of Botany, EarlyView.
Abstract Premise The coloration of flowers is caused by wavelength‐selective absorption by pigments and scattering of light by floral structures. Although the molecular, physiological, and chemical properties of floral pigments have been studied in considerable detail, how floral structures contribute to the visual signal remains largely unknown.
Larissa De Paola   +5 more
wiley   +1 more source

The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The flow diagram outlines the chemical induction of breast tumors through a single intraperitoneal dose of MNU. Tumor development was assessed using ultrasound and clinical examination. After 14 weeks, mammary tissue was collected and histologically analyzed to evaluate structural similarities between sows and humans, the carcinogenic potential of MNU,
Claudia Elizabeth Vera‐Tizatl   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy