Results 41 to 50 of about 267,305 (204)
KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion
Advanced Science, EarlyView.Phosphorylation of ABHD17C induced by KRASmut/ERK signaling facilitates ALOX15B depalmitoylation and degradation via the CUL4/DDB1/DCAF10 complex, thereby enabling KRASmut‐PDAC cell to evade ferroptosis. Methyl protodioscin inhibits KRASmut‐PDAC progression by disrupting the ABHD17C/ALOX15B interaction and inducing ferroptosis, which represents a ...
Man Li +12 more
wiley +1 more source
Viral RNA at two stages of reovirus infection is required for the induction of necroptosis [PDF]
, 2017 Necroptosis, a regulated form of necrotic cell death, requires the activation of the RIP3 kinase. Here, we identify that infection of host cells with reovirus can result in necroptosis.
Berger, Angela K +6 more
core +2 more sources
Advanced Science, EarlyView.Indole‐3‐acetic acid (3‐IAA) derived from gut P. distasonis binds to AhR in bladder cancer cells and downregulates FASN transcription, thereby increasing sensitivity to ferroptosis and suppressing the development of bladder tumors. Specifically, 3‐IAA treatment leads to an increase in the proportion of PC/PE‐PUFAs and a decrease in the proportions of ...
Weijia Li +16 more
wiley +1 more source
Organocatalytic C─O Bond Cleavage and Asymmetric Transformations via [1,3]‐Sigmatropic Rearrangement
Advanced Science, EarlyView.A direct asymmetric strategy for fulfilling the functional group transfer by aryl ether cleavage and migration is developed, representing the first Brønsted base‐catalyzed asymmetric [1,3]‐sigmatropic rearrangement reaction. The resulting chiral benzofuran products generated through this strategy exhibit significant 3D‐dimensionality and demonstrate ...
Lei Peng +7 more
wiley +1 more source
An Affect-Rich Neural Conversational Model with Biased Attention and Weighted Cross-Entropy Loss
, 2018 Affect conveys important implicit information in human communication. Having the capability to correctly express affect during human-machine conversations is one of the major milestones in artificial intelligence.
Miao, Chunyan, Wang, Di, Zhong, Peixiang
core +1 more source
Advanced Science, EarlyView.Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen +8 more
wiley +1 more source
Universal behaviour of diatomic halo states and the mass sensitivity of their properties
, 2019 The scattering and spectroscopic properties of molecular halo states can serve as sensitive probes of the constancy of the electron-to-proton mass ratio $\beta=m_e/m_p$.
Owens, Alec, Špirko, Vladimir
core +1 more source
Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype
Advanced Science, EarlyView.This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez +20 more
wiley +1 more source
Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation
Advanced Science, EarlyView.PANoptosis activation is an effective therapeutic target during mastitis progression, and Gasdermin D activation is key factor contributing to blood milk barrier damage during mastitis, while cyanidin 3‐O‐galactoside can inhibit these targets to exert a protective effect. Therefore, the extraction of key active ingredients from plants for the treatment
Rui Feng +23 more
wiley +1 more source
Advanced Science, EarlyView.In ESCC patients, SNORA58 exhibits heterogeneous expression patterns. Its aberrant overexpression stabilizes CTCF by inhibiting ubiquitin‐mediated degradation, leading to the attenuation of JNK1‐mediated ferroptosis induced by radiotherapy through disruption of intracellular iron homeostasis, and ultimately contributes to radioresistance ...
Yinli Zheng +14 more
wiley +1 more source