Results 51 to 60 of about 29,684 (188)

Conscientious Objection in Euthanasia and Voluntary Assisted Dying From the Perspective of Stakeholders: A Meta‐Synthesis

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim Analyse the meaning of conscientious objection to euthanasia and/or physician‐assisted suicide from the perspective of health professionals, students, patients, family members and regulations. Design Qualitative systematic review. This review was informed by the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA ...
Rosa Pérez‐Capellades, Sergio Ramos‐Pozón, Daniel Pasten‐Araya, Anna Falcó‐Pegueroles   +3 more
wiley   +1 more source

Unveiling Disparities and Missed Opportunities in Vitamin A Supplementation Among Children Under Five in Ethiopia

Maternal &Child Nutrition, EarlyView.
Vitamin A supplementation (VAS) coverage in Ethiopia remains low (21%), with substantial inequities favoring wealthier, urban, and agrarian households, and missed opportunities to integrate VAS with health services like measles vaccination. Improving coverage, equity, and resilience requires expanding access, tailoring delivery approaches, and ...
Tsedey Moges, Meron Girma, Alemnesh Petros, Nardos Birru, Alemayehu Hussen, Meseret Woldeyohannes, Abiy Tefera, Tadesse Kebebe, Berhanu Wodajo, Getachew Tollera, Mesay Hailu, Stanley Chitekwe, Hiwot Darsene, Kidist Woldesenbet, Kaleab Baye, Masresha Tessema, Ramadhani Noor   +16 more
wiley   +1 more source

Whole‐body hot water immersion effect on cerebral haemodynamics and subsequent cerebrovascular reactivity to carbon dioxide

Experimental Physiology, EarlyView.
Abstract To test the hypothesis that hot water immersion (HWI) improves cerebrovascular function via shear‐mediated mechanisms, this study determined cerebrovascular reactivity to carbon dioxide (CVRCO2${\mathrm{CV}}{{\mathrm{R}}_{{\mathrm{C}}{{\mathrm{O}}_2}}}$) before and after 60 min of 39°C HWI and a 21°C air control (CON) in 15 healthy ...
Samuel F. Leaney, Ester Tommasini, Guto W. Hughes, Alison M. Shepherd, Nyah D. Kingdon, Justin S. Lawley, Geoff B. Coombs, Jonathan P. Moore, Samuel J. Oliver   +8 more
wiley   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta‐Analysis of the European Myeloma Network (EMN)

American Journal of Hematology, Volume 101, Issue 9, Page 2353-2370, September 2026.
Our meta‐analysis showed significant improvement of PFS with lenalidomide, proteasome inhibitors, and CD38‐based therapies. A significant OS benefit was noted only with lenalidomide in transplant‐eligible (TE) patients, while CD38‐directed therapy showed a trend toward improved OS.
Heinz Ludwig, Evangelos Terpos, Francesca Gay, Niels W. C. J. van de Donk, Sarah Bernhard, Monika Engelhardt, Gordon Cook, Fredrik Schjesvold, Hermann Einsele, Graham Jackson, Charlotte Pawlyn, María‐Victoria Mateos, Sonja Zweegman, Martin Schreder, Meral Beksaç, Christoph Driessen, Enrique M. Ocio, Rakesh Popat, Leo Rasche, Cyrille Touzeau, Pellegrino Musto, Annemiek Broijl, Meletios Dimopoulos, Roman Hajek, Mario Boccadoro, Pieter Sonneveld   +25 more
wiley   +1 more source

The oscillatory response of the electroretinogram and neuronal adaptation

Acta Ophthalmologica, Volume 104, Issue 6, Page 616-637, September 2026.
Abstract After more than 50 years, there still remains a challenge and an interest to know more as well as extend and deepen our understanding of the small rapid wavelets, the oscillatory potentials (OPs), of the electroretinogram (ERG) and the neuronal adaptation of the retina.
Lillemor Wachtmeister, Anders Eklund
wiley   +1 more source

PCK2 Inhibition Reverses Cisplatin Resistance of Non‐Small Cell Lung Cancer by Triggering Ferroptosis

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Metabolic enzyme PCK2 is aberrantly upregulated in cisplatin‐resistant NSCLC cells, which inhibits ferroptosis and ultimately facilitates tumor chemoresistance. The small‐molecule inhibitor RGB‐286638 directly binds to the key R454 functional site of PCK2 protein, efficiently inhibits PCK2 expression, and rescues PCK2‐mediated ferroptosis suppression ...
Jing Liu, Ziyan Wang, Chen Gu, Yili Chen, Yang Yang, Jianjie Zhu, Yihua Zhang, Yuna Shao, Xiaodong Pang, Yujie Ge, Huiwen Qian, Jian‐an Huang, Zeyi Liu, Yuanyuan Zeng, Cheng Ji   +14 more
wiley   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, Volume 73, Issue 8, August 2026.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, Volume 30, Issue 4, Page 460-470, August 2026.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Scanner‐agnostic artificial intelligence approach for fast bone scintigraphy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 8, August 2026.
Abstract Purpose Current bone scintigraphy protocols often demand full‐count, 10–15 min scans to preserve image quality, and existing deep‐learning (DL) denoisers typically need to be retrained or retuned for each camera manufacturer. We introduce a scanner‐agnostic adaptive‐diffusion U‐Net designed to reconstruct diagnostic‐grade images from half‐time
Vinicius de Oliveira Menezes, Cleiton Cavalcante Queiroz, Antônio Augusto Silva Oliveira, Aurílio José dos Santos Filho, Allisson Francisco de Morais, Adriano de Oliveira Vigário, Maria Eduarda Flamini, Felipe Alves Mourato, Tsang Ing Ren, Marcos Antônio Dórea Machado   +9 more
wiley   +1 more source