Results 41 to 50 of about 29,684 (188)

The Role of Patients' Treatment Expectations in Ventricular Assist Device Support: Results From a Convergent Mixed Methods Study

Artificial Organs, EarlyView.
This mixed methods study aimed to: (i) identify treatment expectations held by individuals with a ventricular assist device (VAD), (ii) assess the extent to which these expectations have been met, and (iii) examine how treatment expectations relate to VAD‐specific health‐related quality of life (HRQoL) ABSTRACT Objectives Treatment expectations ...
Simon Felix Zerth, Bernd Niemann, Miriam Salzmann‐Djufri, Sandra Semmig‐Könze, Katharina Tigges‐Limmer, Yvonne Brocks, Monika Sadlonova, Anna Markser, Tanja Zimmermann, Lara Kristin Oldach, Stefan Salzmann   +10 more
wiley   +1 more source

Shaping the Flow: Impact of Blade Shape on Performance and Hemocompatibility in Rotodynamic Blood Pumps

Artificial Organs, EarlyView.
Blade shapes (leading‐edge geometry and thickness) in rotodynamic blood pumps were systematically evaluated. Thinner blades improve pump efficiency by reducing blockage effects, while neither blade thickness nor leading‐edge geometry shows clear hemocompatibility benefits. Overall, blade shape has a limited impact on hemocompatibility, indicating it is
Benjamin Torner, Simon Klocker, Niccolò Crescenti, Aldo J. Suria, Harald Reithofer, Michael Hübler, Daniel Zimpfer, Marcus Granegger   +7 more
wiley   +1 more source

Efficacy of Antimicrobial Silver‐Plated Dressings Compared to Usual Care in Preventing Left Ventricular Assist Device Driveline Infections

Artificial Organs, EarlyView.
Integrating silver‐plated wound dressings into DLES care presents a safe and effective strategy for DLI prevention. Key findings include a 100% infection‐free rate in the Silverlon group, no NPWT and hospital readmission in the Silverlon group, and no severe DESTINE stages (3, 4) in the Silverlon group.
Barbara Veiter, Martina Socha, Christiane Marko, Nesibe Seyda Colak, Alexandra Kuhn, Hebe Al Asadi, Julia Riebandt, Roxana Moayedifar, Daniel Zimpfer, Thomas Schlöglhofer   +9 more
wiley   +1 more source

Dysregulated TIE‐2 expression is associated with blood‐brain barrier leakiness and Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Ince et al., have analysed TIE‐1 and ‐2 expression in human brain tissue, including microvessel‐enriched fractions (MVF) and covering a spectrum of AD‐associated pathology, and in CSF from independent cohorts spanning a clinical spectrum from normal cognition to AD.
Selvi Ince, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Carey Gleason, Barbara B. Bendlin, Ozioma Okonkwo, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Seth Love, J. Scott Miners   +12 more
wiley   +1 more source

NRF2/xCT‐Mediated Antioxidant Adaptation Attenuates Apoptosis Induced by ASCT2 Inhibition in Prostate Cancer

Cancer Science, EarlyView.
ASCT2 inhibition induces ROS accumulation and activates NRF2‐dependent xCT upregulation in prostate cancer. This adaptive response partially supports residual cystine acquisition and glutathione synthesis, whereas combined ASCT2 and xCT inhibition disrupts redox compensation and predominantly promotes apoptotic cell death.
Jiaxing Wei, Yasutaka Yamada, Takaaki Tamura, Masahiro Sugiura, Xue Zhao, Meng Ni, Adilan Aierken, Tomokazu Sazuka, Yusuke Imamura, Shinichi Sakamoto   +9 more
wiley   +1 more source

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, EarlyView.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

Factors Influencing Nurses' Participation in Voluntary‐Assisted Dying: A National Cross‐Sectional Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To identify nurse practitioners' and registered nurses' willingness to participate in voluntary assisted dying, and the factors that influence these decisions. Design A cross‐sectional design. Methods An online survey was disseminated to members of 16 professional nursing organisations and associations between April and August 2024 ...
Jayne Hewitt, Ann Bonner, Rachel Wardrop, Margaret O'Connor, Ilse Berquier, Joan Carlini, Melissa Bloomer   +6 more
wiley   +1 more source

Ventricular Tachycardia Ablation in Structural Heart Disease With LVEF > 35%: Clinical Outcomes and Recurrence Patterns

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background In patients with structural heart disease (SHD) and moderately impaired left ventricular ejection fraction (LVEF > 35%), data on outcomes after ventricular tachycardia (VT) ablation remain limited. This analysis focuses on VT recurrence after ablation in patients presenting with sustained VT and LVEF > 35% within a secondary ...
Said‐Elias Waezsasa, Moneeb Khalaph, Martin Braun, Thomas Fink, Vanessa Sciacca, Nadica Trajkovska, Philipp Lucas, Ersan Akkaya, Maxim Didenko, Mustapha El Hamriti, Guram Imnadze, Denise Guckel, Christian Sohns, Philipp Sommer, Angeliki Darma   +14 more
wiley   +1 more source

USP30 inhibits wound healing in diabetic foot ulcers by promoting TRAF6‐induced ferroptosis and angiogenesis inhibition

Journal of Diabetes Investigation, EarlyView.
High glucose upregulates USP30 in HUVECs, which deubiquitinates and stabilizes TRAF6. Stabilized TRAF6 suppresses GPX4 and SLC7A11, increases ROS/MDA/lipid peroxidation, and activates ferroptosis and apoptosis, leading to impaired angiogenesis and delayed wound healing.
Jingjing Yuan, Shuang Sui, Zhenghua Yang, Kaiwen Zhang, Qiang Hu   +4 more
wiley   +1 more source

Variability in Vascular Access Device Use, Dwell Time and Failure: Insights From Routine Nursing Documentation in a Multicentre Cohort Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aims To describe and compare institutional patterns of vascular access device use, dwell time, and failure, and to explore their implications for nursing practice. Design Retrospective multicentre observational cohort study. Methods Routinely collected nursing records of vascular access device insertion and removal were analysed from seven ...
Ismael Fernández‐Fernández, Enrique Castro‐Sánchez, Miguel Ángel Rodríguez‐Calero, Jesús Bujalance‐Hoyos, José Luís Cobo‐Sánchez, Gaizka Parra‐García, Maria Antonia Cubero‐Pérez, Juan Manuel García‐Garrido, Ian Blanco‐Mavillard   +8 more
wiley   +1 more source