Results 41 to 50 of about 218,284 (346)

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Videolaringoscopios Pentax-AWS y Glidescope como alternativa al laringoscopio Macintosh en la dificultad de intubación prevista

Revista Electrónica de AnestesiaR, 1970
La dificultad y la imposibilidad para la intubación orotraqueal (IOT) suponen la principal causa de morbilidad y mortalidad de causa anestésica. Los videolaringoscopios (VL) se han desarrollado para reducir la dificultad de intubación laríngea ...
Belén Cobo García
doaj   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Detect Windows Code Injection by Cross-validating Stack and VAD Information

Journal of Harbin University of Science and Technology
Windows 32/64-bit code injection attacks are a common attack technique by malware. In the field of memory forensics, the existing code injection attack detection technologies cannot handle dynamic content in terms of verification integrity, and cannot be
ZHAI Jiqiang, HAN Xu, WANG Jiaqian, SUN Haixu, YANG Hailu   +4 more
doaj   +1 more source

Manejo de la vía aérea en un paciente con secuencia de Pierre Robin para la cirugía de distracción osteogénica mandibular

Revista Electrónica de AnestesiaR, 2015
El síndrome o secuencia de Pierre Robin (SPR) es una rara afección genética con una incidencia de 1 por cada 8.500 recién nacidos, descrita en 1923 por Robin. Se caracteriza por la triada clásica de glosoptosis, obstrucción de la vía aérea y alteraciones
Rosana Guerrero Domínguez, Daniel López-Herrera Rodríguez, Jesús Acosta Martínez   +2 more
doaj   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Perilipin‐2‐Anchored Lipid Droplet‐Targeting Phototheranostics

Angewandte Chemie, EarlyView.
This study reports two NIR theranostic dyes, C‐BDP‐OH and C‐BDP‐OMe. C‐BDP‐OMe targets lipid droplets via a dual‐anchoring mechanism with PLIN2, enabling wash‐free tumor imaging. With 62.6% photothermal conversion efficiency, it achieves tumor ablation by downregulating PLIN2, disrupting LD‐mitochondria crosstalk, and triggering apoptosis and ...
Lipeng Zhang, Jiyoung Yoo, Juan Bai, Sunghyun Kim, Yesim Bakan, Yongbin Zhang, Fangjun Huo, Jingying Zhou, Caixia Yin, Jong Seung Kim   +9 more
wiley   +2 more sources

¿Vía Aérea Difícil y Cirugía Ambulatoria…?

Revista Electrónica de AnestesiaR, 2013
Esta revisión tiene como objetivos revisar 2 aspectos clave del manejo de la Vía Aérea Difícil (VAD) en cirugía ambulatoria. El proceso de selección de los pacientes con VAD conocida y el equipamiento que necesita el carro de VA para el manejo de una VAD
Briseida V Arrázola Cabrera, Jolanta B Tomaszewska, Andrzej P Walczak, Marisa Mariscal Flores   +3 more
doaj   +1 more source

An advanced universal circulatory assist device for left and right ventricular support: First report of an acute in vivo implantCentral MessagePerspective

JTCVS Open, 2020
Background: The Advanced ventricular assist device (Advanced VAD) is designed as a universal pump intended to prevent backflow in the event of pump stoppage, to maintain physiological pulse pressure, and to be used as both a left and right VAD.
Takuma Miyamoto, MD, PhD, Yuichiro Kado, MD, PhD, David J. Horvath, MSME, Barry D. Kuban, BS, Shiva Sale, MD, Kiyotaka Fukamachi, MD, PhD, Jamshid H. Karimov, MD, PhD   +6 more
doaj   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source