Results 41 to 50 of about 311,841 (295)

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy

Advanced Science, EarlyView.
A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan, Yuling Xu, Ting Yu, Yang Li, Xin Jiang, Haoyu Jin, Haitao Li, Youyu Zhang, Peng Yin, Jong Seung Kim   +9 more
wiley   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

An advanced universal circulatory assist device for left and right ventricular support: First report of an acute in vivo implantCentral MessagePerspective

JTCVS Open, 2020
Background: The Advanced ventricular assist device (Advanced VAD) is designed as a universal pump intended to prevent backflow in the event of pump stoppage, to maintain physiological pulse pressure, and to be used as both a left and right VAD.
Takuma Miyamoto, MD, PhD, Yuichiro Kado, MD, PhD, David J. Horvath, MSME, Barry D. Kuban, BS, Shiva Sale, MD, Kiyotaka Fukamachi, MD, PhD, Jamshid H. Karimov, MD, PhD   +6 more
doaj   +1 more source

Detect Windows Code Injection by Cross-validating Stack and VAD Information

Journal of Harbin University of Science and Technology
Windows 32/64-bit code injection attacks are a common attack technique by malware. In the field of memory forensics, the existing code injection attack detection technologies cannot handle dynamic content in terms of verification integrity, and cannot be
ZHAI Jiqiang, HAN Xu, WANG Jiaqian, SUN Haixu, YANG Hailu   +4 more
doaj   +1 more source

Manejo de la vía aérea en un paciente con secuencia de Pierre Robin para la cirugía de distracción osteogénica mandibular

Revista Electrónica de AnestesiaR, 2015
El síndrome o secuencia de Pierre Robin (SPR) es una rara afección genética con una incidencia de 1 por cada 8.500 recién nacidos, descrita en 1923 por Robin. Se caracteriza por la triada clásica de glosoptosis, obstrucción de la vía aérea y alteraciones
Rosana Guerrero Domínguez, Daniel López-Herrera Rodríguez, Jesús Acosta Martínez   +2 more
doaj   +1 more source

Replenishment of vitamin A for 7 days partially restored hepatic gene expressions altered by its deficiency in rats

Frontiers in Nutrition, 2022
We investigated the effects of vitamin A (VA) status on metabolism of Zucker rats with different genders and genotypes, and of short-term refeeding of a VA sufficient (VAS) diet on VA deficient (VAD) animals.
Yan Zhang, Kui Tian, Guoxun Chen
doaj   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

¿Vía Aérea Difícil y Cirugía Ambulatoria…?

Revista Electrónica de AnestesiaR, 2013
Esta revisión tiene como objetivos revisar 2 aspectos clave del manejo de la Vía Aérea Difícil (VAD) en cirugía ambulatoria. El proceso de selección de los pacientes con VAD conocida y el equipamiento que necesita el carro de VA para el manejo de una VAD
Briseida V Arrázola Cabrera, Jolanta B Tomaszewska, Andrzej P Walczak, Marisa Mariscal Flores   +3 more
doaj   +1 more source