Results 61 to 70 of about 29,684 (188)

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, Volume 13, Issue 43, 3 August 2026.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Vascular cognitive impairment (VCI), the second leading cause of dementia, is characterized by heterogeneous pathophysiology and a potentially reversible early phase, underscoring the need for timely identification. This review synthesizes advances across four complementary domains – targeted cognitive assessments, imaging biomarkers ...
Wenqi Song, Xiaoqun Liu, Tianrui Yu, Yuanyuan Xiang, Peijie Fu, Moxin Wu, Xiaoping Yin, Xiaorong Zhang, Zhiying Chen   +8 more
wiley   +1 more source

Structural Restoration of an Unruptured Vertebral Artery Dissection Following Autologous Mesenchymal Stem Cell Therapy: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Vertebral artery dissection (VAD) is a recognized cause of ischemic stroke, and current management relies on antithrombotic therapy that is not specifically directed at structural repair of the arterial wall. We report a man in his mid‐50s who presented with a sudden, severe right occipital headache after a golf swing and had a history of a ...
Hyungchang Kang, Eung Jae Lee, Moon Hyoung Lee, Hyun Soo Kim   +3 more
wiley   +1 more source

A‐optimal model‐based design of experiments for processes with uncertain inputs

The Canadian Journal of Chemical Engineering, Volume 104, Issue 8, Page 4307-4321, August 2026.
Abstract Model‐based design of experiments (MBDoE) techniques are tools for selecting experimental conditions that enable accurate parameter estimation for mechanistic models. Most MBDoE approaches assume that the selected experimental conditions will be implemented perfectly, without uncertainties in the independent variables.
Bright Ofori, Iman Moshiritabrizi, Anh‐Duong Vo, Kimberley B. McAuley   +3 more
wiley   +1 more source

Synergistic Interaction Between HPV-16 E7 Oncoprotein and Severe Vitamin A Deficiency in Regulating Adaptive Immunity in a Preclinical Cervical Cancer Model. [PDF]

J Med Virol
Chávez-Ríos A, López-Ruiz C, García-Aguirre IA, Ocadiz-Delgado R, Garcia-Sierra F, Hernández-Pando R, Lizcano-Meneses S, Gariglio P.   +7 more
europepmc   +1 more source

Prevalence of Clinical Vitamin A Deficiency and Associated Factors Among Children Aged 24–59 Months in Finote Selam Town, Ethiopia: A Community Based Cross‐Sectional Study, 2022

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aim Vitamin A deficiency is a public health problem in developing countries including Ethiopia. Thus, its prevalence and associated factors in each locality is essential for tackling the problem since the cause differs across geographical areas and community to community.
Molla Mekuria, Getachew Tesfaw Walle, Zewdie Aderaw, Mekuriaw Alemu Tenaw, Etsehiwot Debe Worku, Melese Linger Endalifer   +5 more
wiley   +1 more source

Early-Life Vitamin A Deficiency Induces Tissue-Specific Oxylipin Remodeling and Hepatic Inflammation. [PDF]

Nutrients
Arballo J, Yang J, Engle-Stone R, ZhaoZhao K, Tang M, Ji P.   +5 more
europepmc   +1 more source

Sjuttonhundratalets vetenskap – vad hände och vad händer?

, 2008
This essay documents the historiography of 18th century Swedish science and its main organizers Johan Nordström and his successor as professor of history of science and ideas at Uppsala University Sten Lindroth, active within this discipline until 1979.
openaire   +1 more source