Results 71 to 80 of about 218,284 (346)

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Liability for damage resulting from wildlife - vehicle collision

, 2021
Jelen szakdolgozatban arra vállalkozok, hogy megismertessem a gépjármű és a vad ütközésével kapcsolatos felelősségi szabályokat a bírói gyakorlat tükrében, nem nélkülözve saját véleményemet a problémára adható lehetséges megoldásokkal együtt.
Bogád, Tamás Dávid
core  

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

40 Jahre Vereinigung für Afrikawissenschaften in Deutschland (VAD), 1969-2009

, 2009
Brahm F. 40 Jahre Vereinigung für Afrikawissenschaften in Deutschland (VAD), 1969-2009.
Brahm, Felix
core  

The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta‐Analysis of the European Myeloma Network (EMN)

American Journal of Hematology, EarlyView.
Our meta‐analysis showed significant improvement of PFS with lenalidomide, proteasome inhibitors, and CD38‐based therapies. A significant OS benefit was noted only with lenalidomide in transplant‐eligible (TE) patients, while CD38‐directed therapy showed a trend toward improved OS.
Heinz Ludwig, Evangelos Terpos, Francesca Gay, Niels W. C. J. van de Donk, Sarah Bernhard, Monika Engelhardt, Gordon Cook, Fredrik Schjesvold, Hermann Einsele, Graham Jackson, Charlotte Pawlyn, María‐Victoria Mateos, Sonja Zweegman, Martin Schreder, Meral Beksaç, Christoph Driessen, Enrique M. Ocio, Rakesh Popat, Leo Rasche, Cyrille Touzeau, Pellegrino Musto, Annemiek Broijl, Meletios Dimopoulos, Roman Hajek, Mario Boccadoro, Pieter Sonneveld   +25 more
wiley   +1 more source

Synergistic Interaction Between HPV-16 E7 Oncoprotein and Severe Vitamin A Deficiency in Regulating Adaptive Immunity in a Preclinical Cervical Cancer Model. [PDF]

J Med Virol
ABSTRACT Persistent infection with High‐Risk Human Papillomavirus (HR‐HPV), particularly HPV‐16, is the main driver of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). However, HR‐HPV infection alone is insufficient for malignant progression and nutritional cofactors such as Vitamin A deficiency, may influence cervical neoplasia ...
Chávez-Ríos A, López-Ruiz C, García-Aguirre IA, Ocadiz-Delgado R, Garcia-Sierra F, Hernández-Pando R, Lizcano-Meneses S, Gariglio P.   +7 more
europepmc   +2 more sources

VAD devices for heart failure treatment: a cost analysis

, 2022
reservedL’insufficienza cardiaca è una condizione sempre più comune nel mondo ed è associata ad un’elevata mortalità. È una condizione cronica caratterizzata da un progressivo allargamento del ventricolo sinistro.
DE ROSSI, FRANCESCO
core  

Los prototipos

, 2019
If in the first issue of VAD. veredes, arquitectura y divulgación we looked at ‘the beginnings’, at those beginnings and principles that provide in a tangible or symbolic way what wishes to exist, now we want to explore in depth the parameters belonging ...
de Miguel, Sergio
core  

Knud Vad, órgano (Dinamarca)

, 1973
Concierto interpretado por Knud Vad. Inició sus estudios con su padre Peter Vad, renombrado organista de ese país, y desde los 13 años colaboró con él en los servicios musicales de la iglesia; ingresó al Conservatorio Real de Dinamarca en Copenhague ...
Vad, Knud - Órgano (Dinamarca)
core  

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease–Like Autoinflammatory Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease represents a prototypical polygenic systemic autoinflammatory disease, characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still disease remains unreported.
Longfang Chen, Qihua Dai, Yu Xiao, Jialin Dai, Mengyan Wang, Yuning Ma, Yujie Shen, Zhimo Xu, Jianfen Meng, Xia Chen, Da Yi, Yue Sun, Hui Shi, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Tingting Liu, Jialin Teng, Chengde Yang, Jinchao Jia, Qiongyi Hu   +23 more
wiley   +1 more source