Results 181 to 190 of about 1,435,723 (230)

Advances in microbicide vaginal rings

Antiviral Research, 2010
Vaginal ring devices capable of providing sustained/controlled release of incorporated actives are already marketed for steroidal contraception and estrogen replacement therapy. In recent years, there has been considerable interest in developing similar ring devices for the administration of microbicidal compounds to prevent vaginal HIV transmission ...
Malcolm, Karl, Edwards, K-L., Kiser, P., Romano, J., Smith, T.   +4 more
openaire   +3 more sources

Development and verification of mechanistic vaginal absorption and metabolism model to predict systemic exposure after vaginal ring and gel application

British Journal of Clinical Pharmacology
The current work describes the development of mechanistic vaginal absorption and metabolism model within Simcyp Simulator to predict systemic concentrations following vaginal application of ring and gel formulations.
Kanika Thakur, Krishna C Telaprolu, Daniel Paterson, Farzaneh Salem, Sumit Arora, Sebastian Polak   +5 more
semanticscholar   +1 more source

Vaginal Ring an HT Alternative

The Nurse Practitioner, 2004
On May 31 2002 the Womens Health Initiative (WHI) announced that the combined estrogen and progestin arm of the study was halted because the numbers of breast cancers blood clots and cardiac events exceeded the preset limits. In February 2004 the estrogen-only arm of the study was stopped as well thus ending the intervention phase of the study.
Mary M, Cothran, Sandra, Engberg
openaire   +2 more sources

Contraceptive vaginal rings: a review

Contraception, 2010
Development efforts on contraceptive vaginal rings were initiated over 40 years ago based on two principles: the capacity of the vaginal epithelium to absorb steroids and the capacity of elastomers to release these hormones at a nearly constant rate. Numerous models of contraceptive vaginal rings (CVRs) have been studied, but only two have reached the ...
Vivian, Brache, Anibal, Faundes
openaire   +2 more sources

Vaginal health in contraceptive vaginal ring users – A review

The European Journal of Contraception & Reproductive Health Care, 2013
To provide an overview of the available data from clinical studies of vaginal conditions in women who use a vaginal ring as a contraceptive.A systematic review of the literature.Millions of women have already used the ethylene vinyl acetate vaginal ring that releases ethinylestradiol and etonogestrel for contraception.
Iñaki, Lete, María C, Cuesta, Juan M, Marín, Sandra, Guerra   +3 more
openaire   +2 more sources

A technology evaluation of Annovera: a segesterone acetate and ethinyl estradiol vaginal ring used to prevent pregnancy for up to one year

Expert Opinion on Drug Delivery, 2020
Introduction The segesterone acetate and ethinyl estradiol contraceptive vaginal ring (SA/EE CVR) was FDA-approved in August 2018 and is now available in the U.S.
E. Micks, J. Jensen
semanticscholar   +1 more source

The Contraceptive Vaginal Ring

2020
Contraceptive vaginal rings (CVR) are plastic polymer rings containing sex steroids that are directly absorbed through the vaginal epithelium into systemic circulation for highly effective contraception without the need for daily dosing. There are currently two CVRs that are FDA-approved for use in the United States. The ENG/EE ring (NuvaRing) contains
Rachel S. Mandelbaum, Donna Shoupe
openaire   +1 more source

Contraceptive vaginal ring reduces lamotrigine levels

Epilepsy & Behavior, 2020
The objective of the study was to describe the effect of the vaginal ring and transdermal patch on lamotrigine serum levels in women with epilepsy.Previous studies demonstrate that oral hormonal contraceptives containing synthetic estrogen increase lamotrigine clearance through induction of glucuronidation.
Alexa, King, Elizabeth, Bachman, Micheal P, Macken, Jungwha, Lee, Elizabeth E, Gerard   +4 more
openaire   +2 more sources

Current status of contraceptive vaginal rings

Contraception, 2013
Contraceptive vaginal rings (CVR) offer a new, effective contraceptive option, expanding the available choices of hormonal contraception. Various ring prototypes have been evaluated: progestin-only rings and combined progestin-estrogen rings, as well as different combination of progestins and estrogens.
Vivian, Brache, Luis José, Payán, Aníbal, Faundes   +2 more
openaire   +2 more sources

The Vaginal Ring: Expelled or Misplaced?

Journal of Ultrasound in Medicine, 2009
aginal administration of hormones, contraceptive or replacement hormone therapy, is rising in market popularity. The vaginal ring, or NuvaRing (Organon USA Inc, Roseland, NJ), is estimated to have more than 1 million users in more than 25 countries, including the United States and Canada.
Mousumi, Bhaduri, Lesley K, Carr, Sheila, Dunn, Phyllis, Glanc   +3 more
openaire   +2 more sources