Results 91 to 100 of about 45,261 (260)

Personalized multichannel transcranial direct current electrical stimulation (tDCS) in drug‐resistant epilepsy: A SEEG based open‐labeled study

Epilepsia Open, EarlyView.
Abstract Objective To evaluate the effects of personalized multichannel tDCS on seizure frequency, severity, quality of life, and psychiatric comorbidities in patients with drug‐resistant focal epilepsy. Secondary goals include assessing the safety and feasibility of this approach.
Fabrice Bartolomei, Maëva Daoud, Megane Delourme, Sophie Tardoski, Julia Makhalova, Eya Bourguiba, Samuel Medina Villalon, Stanislas Lagarde, Fabrice Wendling, Giulio Ruffini, Ricardo Salvador, Francesca Pizzo, Bernard Giusiano   +12 more
wiley   +1 more source

Resting‐state functional connectivity changes with microburst vagus nerve stimulation therapy

Epilepsia Open, EarlyView.
Abstract Objective Microburst vagus nerve stimulation (μVNS) may reduce seizure frequency in drug‐resistant epilepsy (DRE) via targeted thalamic plasticity. We prospectively investigated the role of thalamic resting‐state functional connectivity (rsFC) in μVNS effects and hypothesized a relationship between thalamic rsFC and long‐term seizure frequency
Jane B. Allendorfer, Rodolphe Nenert, Elhum Shamshiri, Giovanni Ranuzzi, Jason Begnaud, Ryan Verner, Jerzy P. Szaflarski, for the Microburst Study Group, Rebecca O’Dwyer, Michael Macken, Blake Newman, Cornelia Drees, Danielle McDermott, Lesley Kaye, Mesha Gay Brown, Muhammad Zafar, William Tatum, Selim Benbadis, Pegah Afra, Zeenat Jaisani, Kristl Vonck   +20 more
wiley   +1 more source

Late‐onset asystole associated with vagal nerve stimulation

Epilepsia Open, EarlyView.
Abstract Vagal nerve stimulation (VNS) is a form of neuromodulation that is an established adjunct in the management of drug‐resistant epilepsy. The common side effects of VNS are cough, dysphonia, or shortness of breath, which are often mild and do not require discontinuation of therapy.
Divya Nagabushana, Huan Huynh, Mark D. McCauley, Anna Serafini   +3 more
wiley   +1 more source

The landscape of epilepsy surgery in older adults: Challenges and opportunities

Epilepsia Open, EarlyView.
Abstract The prevalence of epilepsy increases with age, and with the aging population, the number of drug‐resistant epilepsy (DRE) cases is expected to rise. However, epilepsy surgery remains underutilized and is typically offered to younger adults. Despite historical hesitancy due to concerns over risks and outcomes, evidence over the last two decades
Vineet Punia
wiley   +1 more source

Exploring the application of ferroelectret nanogenerators in medical engineering

FlexMat, EarlyView.
Abstract Flexible devices derived from piezoelectric materials have gained considerable attention due to their exceptional biocompatibility. Among these, ferroelectret nanogenerators (FENG) is a novel type of flexible piezoelectric device that integrates self‐powering, actuation, and sensing capabilities.
Xianfa Cai, Xiaowen Han, Jiaqi Xie, Yunqi Cao, Wei Li   +4 more
wiley   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Progress of non‐motor symptoms in early‐onset Parkinson's disease

Ibrain, EarlyView.
This study reviews the research progress related to non‐motor symptoms (NMS) in patients with early onset Parkinson's disease (EOPD), including neuropsychiatric symptoms, autonomic dysfunction, sleep disorders, and sensory disorders and also summarizes the characteristics of NMS in the genetic form of Parkinson's disease (PD).
Fanshi Zhang, Aidi Luo, Shusheng Liao, Mei Liu, Jun Zhang, Zucai Xu   +5 more
wiley   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Genetically‐targeted control of the spinal cord and peripheral nervous system

Journal of Intelligent Medicine, EarlyView.
Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano, Victoria Koptelova, Zoya Ahmad, Huiliang (Evan) Wang   +3 more
wiley   +1 more source

Am I safe around you? Attachment figure activation increases perceived security but does not reduce negative interpretations of neutral expressions

Journal of Traumatic Stress, EarlyView.
Abstract Child maltreatment (CM) is associated with social problems, such as loneliness and isolation. One factor that might contribute to these problems is the tendency for individuals who have experienced CM to interpret neutral facial expressions as negative (i.e., negativity bias).
Monique C. Pfaltz, Lara‐Lynn Hautle, Billy Jansson, Sonja Weilenmann, Peter Peyk, Antonia M. Lüönd   +5 more
wiley   +1 more source