Results 71 to 80 of about 942,264 (291)

Vagus Nerve Stimulation Improves Working Memory Performance

, 2017
Vagus nerve stimulation (VNS) is used for treating refractory epilepsy and major depression. While the impact of this treatment on seizures has been established, its impact on human cognition remains equivocal.
Katri Holm, Kai Lehtimäki, Lehtimäki, Kai, Lihua Sun, Peltola, Jukka, Kaisa M. Hartikainen, Jari Peräkylä, Sun, Lihua, Peräkylä, Jari, Hartikainen, Kaisa, Keith H. Ogawa, Ogawa, Keith, Joonas Haapasalo, Holm, Katri, Jukka Peltola, Haapasalo, Joonas   +15 more
core   +1 more source

Differential Tissue‐Coupled Powering for Battery‐Free Injectable Electroceuticals

Advanced Science, EarlyView.
A thread‐like injectable neural stimulator is powered through differential tissue‐coupled powering (DTCP), which harvests RF‐frequency tissue potentials with an elongated receiver while preserving a injectable cross‐section. The system integrates an ASIC, stimulation electrodes, and a portable transmitter, enabling wireless peripheral nerve stimulation,
Han Wu, Sultan Mahmud, Mali Halac, Asif Iftekhar Omi, Domenica Sofia Baez Rodas, Jeremiasz Dados, Chaojun Cheng, Anyu Jiang, Cameron Wallace, Anvi Singh, Erin Patrick, Baibhab Chatterjee, Shriya Srinivasan, Adam Khalifa   +13 more
wiley   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

Protective effects of an interaction between vagus nerve and melatonin on gastric ischemia/reperfusion: the role of oxidative stress [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objectives:Vagal pathways in gastrointestinal tract are the most important pathways that regulate ischemia/reperfusion (I/R).  Gastrointestinal tract is one of the important sources of melatonin production.
Nader Shahrokhi, Mohammad Khaksari, Shahla Nourizad, Nava Shahrokhi Shahrokhi, Zahra Soltani, Ahmad Gholamhosseinian   +5 more
doaj  

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Development of a Multimodal Auricular Vagus Nerve Stimulator with EEG Monitoring Capability

Zhongguo yiliao qixie zazhi
ObjectiveTo address the limitations of existing auricular vagus nerve stimulators, which have a single stimulation mode and are open-loop, a new type of auricular vagus nerve stimulator system was developed.
Xiaohua YU, Guojing WANG, Shijing WU, Hongyun LIU   +3 more
doaj   +1 more source

Optical vagus nerve modulation of heart and respiration via heart-injected retrograde AAV

Scientific Reports, 2021
Vagus nerve stimulation has shown many benefits for disease therapies but current approaches involve imprecise electrical stimulation that gives rise to off-target effects, while the functionally relevant pathways remain poorly understood.
Arjun K. Fontaine, Gregory L. Futia, Pradeep S. Rajendran, Samuel F. Littich, Naoko Mizoguchi, Kalyanam Shivkumar, Jeffrey L. Ardell, Diego Restrepo, John H. Caldwell, Emily A. Gibson, Richard F. ff Weir   +10 more
doaj   +1 more source

Neuroprotection after transient middle cerebral artery occlusion in male rats using kojic acid nanostructured lipid carriers: A behavioral, biochemical, and histological study on hippocampal CA1 region

Animal Models and Experimental Medicine, EarlyView.
This study demonstrates that kojic acid–loaded nanostructured lipid carriers (KA‐NLC) provide significant neuroprotection in a male rat model of middle cerebral artery occlusion (MCAO)–induced stroke. Treatment with KA‐NLCs reduced cerebral edema, improved motor and coordination balance and neurological scores, and enhanced spatial and avoidance memory.
Mobina Gheibi, Erfan Ghadirzadeh, Javid Tebyani, Seyedeh Mohadeseh Moyaedi, Khadijeh Khezri, Majid Saeedi, Ali Siahposht‐Khachaki, Narges Karimi, Melika Pourhossein, Shiva Shadi, Sasan Shafiei, Atena Sharifi‐Razavi   +11 more
wiley   +1 more source

First‐in‐human microelectrode recordings from the vagus nerve during clinical vagus nerve stimulation

Epilepsia Open
Introduction Vagus nerve stimulation (VNS) is an effective treatment for people with drug‐resistant epilepsy. However, its mechanisms of action are poorly understood, including which nerve fibers are activated in humans during VNS in typical clinical ...
Mikaela Patros, David G. S. Farmer, Kegan Moneghetti, Matteo M. Ottaviani, Shobi Sivathamboo, Hugh D. Simpson, Terence J. O'Brien, Vaughan G. Macefield   +7 more
doaj   +1 more source

Vagus Nerve Stimulation for Epilepsy

, 1997
The Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology reports on vagus nerve stimulation (VNS) for ...
J Gordon Millichap
core   +1 more source