Results 71 to 80 of about 1,006,454 (292)

Protective effects of an interaction between vagus nerve and melatonin on gastric ischemia/reperfusion: the role of oxidative stress [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objectives:Vagal pathways in gastrointestinal tract are the most important pathways that regulate ischemia/reperfusion (I/R).  Gastrointestinal tract is one of the important sources of melatonin production.
Nader Shahrokhi, Mohammad Khaksari, Shahla Nourizad, Nava Shahrokhi Shahrokhi, Zahra Soltani, Ahmad Gholamhosseinian   +5 more
doaj  

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Development of a Multimodal Auricular Vagus Nerve Stimulator with EEG Monitoring Capability

Zhongguo yiliao qixie zazhi
ObjectiveTo address the limitations of existing auricular vagus nerve stimulators, which have a single stimulation mode and are open-loop, a new type of auricular vagus nerve stimulator system was developed.
Xiaohua YU, Guojing WANG, Shijing WU, Hongyun LIU   +3 more
doaj   +1 more source

Optical vagus nerve modulation of heart and respiration via heart-injected retrograde AAV

Scientific Reports, 2021
Vagus nerve stimulation has shown many benefits for disease therapies but current approaches involve imprecise electrical stimulation that gives rise to off-target effects, while the functionally relevant pathways remain poorly understood.
Arjun K. Fontaine, Gregory L. Futia, Pradeep S. Rajendran, Samuel F. Littich, Naoko Mizoguchi, Kalyanam Shivkumar, Jeffrey L. Ardell, Diego Restrepo, John H. Caldwell, Emily A. Gibson, Richard F. ff Weir   +10 more
doaj   +1 more source

Vagus Nerve Stimulation for Control of Epilepsy

, 1991
Results of intermittent stimulation of the vagus nerve in four patients with intractable partial seizures are reported from the Department of Neurology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem ...
J Gordon Millichap, Millichap, J. Gordon
core   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

First‐in‐human microelectrode recordings from the vagus nerve during clinical vagus nerve stimulation

Epilepsia Open
Introduction Vagus nerve stimulation (VNS) is an effective treatment for people with drug‐resistant epilepsy. However, its mechanisms of action are poorly understood, including which nerve fibers are activated in humans during VNS in typical clinical ...
Mikaela Patros, David G. S. Farmer, Kegan Moneghetti, Matteo M. Ottaviani, Shobi Sivathamboo, Hugh D. Simpson, Terence J. O'Brien, Vaughan G. Macefield   +7 more
doaj   +1 more source

Probiotic spore‐based bioresponsive drug delivery for reversing inflammatory bowel disease and its associated anxiety and depression

BMEMat, EarlyView.
A probiotic spore‐based drug delivery system (BCS‐Que@ApNPs) provides excellent targeted delivery, bioresponsive drug release, and long‐term retention (over 48 h), making it suitable for oral treatment of inflammatory bowel disease and its associated anxiety and depression.
Qingling Song, Beiyang Xue, Yao Li, Chuangxi Zhou, Junfei Yang, Yunfei Li, Lingwen Ding, Yun Zhang, Hongjuan Zhao, Lei Wang   +9 more
wiley   +1 more source

tVNS Increases Liking of Orally Sampled Low-Fat Foods: A Pilot Study

Frontiers in Human Neuroscience, 2020
Recently a role for the vagus nerve in conditioning food preferences was established in rodents. In a prospective controlled clinical trial in humans, invasive vagus nerve stimulation shifted food choice toward lower fat content. Here we explored whether
Lina Öztürk, Pia Elisa Büning, Pia Elisa Büning, Pia Elisa Büning, Eleni Frangos, Guillaume de Lartigue, Guillaume de Lartigue, Guillaume de Lartigue, Guillaume de Lartigue, Maria G. Veldhuizen, Maria G. Veldhuizen, Maria G. Veldhuizen   +11 more
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source