Results 61 to 70 of about 1,006,454 (292)

Recurrent Neurodevelopmental Disorder Associated With a Dominant‐Negative TOP2B H63Y Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a 7 year‐old boy with severe neurodevelopmental disorder, medically‐refractory epileptic encephalopathy, hyperkinetic movement disorder, hypotonia, cerebral and cerebellar atrophy and hypomyelination who was found to have a heterozygous de novo TOP2B NM_001330700.2:c.187C>T, p.(His63Tyr) variant.
Zong Yi Ha, Leticia Dinatto, Kirsten Meagher, Colleen Guimond, Jan M. Friedman, Peter C. Stirling, Millan S. Patel   +6 more
wiley   +1 more source

Differential effects of vagus nerve stimulation strategies on glycemia and pancreatic secretions

Physiological Reports, 2020
Despite advancements in pharmacotherapies, glycemia is poorly controlled in type 2 diabetic patients. As the vagus nerve regulates energy metabolism, here we evaluated the effect various electrical vagus nerve stimulation strategies have on glycemia and ...
Sophie C. Payne, Glenn Ward, Richard J. MacIsaac, Tomoko Hyakumura, James B. Fallon, Joel Villalobos   +5 more
doaj   +1 more source

Non-invasive vagus nerve stimulation in epilepsy patients enhances cooperative behavior in the prisoner’s dilemma task

Scientific Reports, 2022
The vagus nerve constitutes a key link between the autonomic and the central nervous system. Previous studies provide evidence for the impact of vagal activity on distinct cognitive processes including functions related to social cognition.
Carina R. Oehrn, Lena Molitor, Kristina Krause, Hauke Niehaus, Laura Schmidt, Lukas Hakel, Lars Timmermann, Katja Menzler, Susanne Knake, Immo Weber   +9 more
doaj   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Computational modeling of human vagus nerve stimulation with three-dimensional fascicular morphology [PDF]

APL Bioengineering
Implanted vagus nerve stimulation is FDA-approved to treat epilepsy, depression, and stroke sequelae and is under development for other disorders such as heart failure and rheumatoid arthritis.
Daniel P. Marshall, Aniruddha R. Upadhye, Ozge N. Buyukcelik, Andrew J. Shoffstall, Warren M. Grill, Nicole A. Pelot   +5 more
doaj   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Optimizing non-invasive vagus nerve stimulation for treatment in stroke

Neural Regeneration Research
Stroke remains a leading cause of long-term disability worldwide. There is an unmet need for neuromodulatory therapies that can mitigate against neurovascular injury and potentially promote neurological recovery.
Sheharyar S. Baig, Samantha Dorney, Mudasar Aziz, Simon M. Bell, Ali N. Ali, Li Su, Jessica N. Redgrave, Arshad Majid   +7 more
doaj   +1 more source

Vagus Nerve Stimulation Improves Working Memory Performance

, 2017
Vagus nerve stimulation (VNS) is used for treating refractory epilepsy and major depression. While the impact of this treatment on seizures has been established, its impact on human cognition remains equivocal.
Katri Holm, Kai Lehtimäki, Lehtimäki, Kai, Lihua Sun, Peltola, Jukka, Kaisa M. Hartikainen, Jari Peräkylä, Sun, Lihua, Peräkylä, Jari, Hartikainen, Kaisa, Keith H. Ogawa, Ogawa, Keith, Joonas Haapasalo, Holm, Katri, Jukka Peltola, Haapasalo, Joonas   +15 more
core   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Transcutaneous vagus nerve stimulation on trigeminal pain processing

, 2020
Brief summary: To assess whether the pain processing (pain threshold, pain intensity) before and after the non-invasive vagus nerve stimulation (nVNS) in healthy ...
Prof. Dr. Arne May, Kuan-Po Peng
core   +1 more source