Results 121 to 130 of about 9,445,211 (322)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Reconstruction of Fine-Spatial-Resolution FY-3D-Based Vegetation Indices to Achieve Farmland-Scale Winter Wheat Yield Estimation via Fusion with Sentinel-2 Data

Remote Sensing
The spatial resolution (250–1000 m) of the FY-3D MERSI is too coarse for agricultural monitoring at the farmland scale (20–30 m). To achieve the winter wheat yield (WWY) at the farmland scale, based on FY-3D, a method framework is developed in this work.
Xijia Zhou, Tao Wang, Wei Zheng, Mingwei Zhang, Yuanyuan Wang   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Joint Optimization of Container Resource Defragmentation and Task Scheduling in Queueing Cloud Computing: A DRL-Based Approach

Future Internet
Container-based virtualization has become pivotal in cloud computing, and resource fragmentation is inevitable due to the frequency of container deployment/termination and the heterogeneous nature of IoT tasks.
Yan Guo, Lan Wei, Cunqun Fan, You Ma, Xiangang Zhao, Henghong He   +5 more
doaj   +1 more source

An empirical learning-based validation procedure for simulation workflow

, 2018
Simulation workflow is a top-level model for the design and control of simulation process. It connects multiple simulation components with time and interaction restrictions to form a complete simulation system.
Lai, Liyuanjun, Liu, Zhuqing, Zhang, Lin
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs.

Journal of the American Medical Association (JAMA), 2016
Varun Gulshan, L. Peng, Marc Coram, Martin C. Stumpe, Derek J. Wu, Arunachalam Narayanaswamy, Subhashini Venugopalan, Kasumi Widner, T. Madams, Jorge A Cuadros, R. Kim, R. Raman, Philip Nelson, J. Mega, D. Webster   +14 more
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

MolProbity: More and better reference data for improved all‐atom structure validation

Protein Science, 2018
Christopher J. Williams, J. Headd, N. Moriarty, M. G. Prisant, Lizbeth L. Videau, Lindsay N. Deis, Vishal Verma, D. Keedy, B. Hintze, Vincent B. Chen, Swati Jain, Steven M. Lewis, W. B. Arendall, J. Snoeyink, P. D. Adams, Simon C. Lovell, J. Richardson, David C Richardson   +17 more
semanticscholar   +1 more source