Results 11 to 20 of about 6,125,000 (281)

Aryl Hydrocarbon Receptor Activation by Benzo[a]pyrene Prevents Development of Septic Shock and Fatal Outcome in a Mouse Model of Systemic Salmonella enterica Infection

Cells, 2022
This study focused on immunomodulatory effects of aryl hydrocarbon receptor (AhR) activation through benzo[a]pyrene (BaP) during systemic bacterial infection.
Christiane Fueldner, Sina Riemschneider, Janine Haupt, Harald Jungnickel, Felix Schulze, Katharina Zoldan, Charlotte Esser, Sunna Hauschildt, Jens Knauer, Andreas Luch, Stefan Kalkhof, Jörg Lehmann   +11 more
doaj   +1 more source

Field validation of a dusting cloth for mycological surveillance of surfaces [PDF]

, 2011
Efficient monitoring of surfaces for spores of filamentous fungi is essential for detecting minor contamination even when air samples test negative for fungi.
Brenier Pinchart, Marie Pierre, Cavarischia, Roberta, Cerquetani, Franco, D'Alessandro, Daniela, Grillot, Renée, Osborn, John Frederik, Vescia, Nicoletta   +6 more
core   +1 more source

Systems validation: application to statistical programs [PDF]

, 2005
BACKGROUND: In 2003, the United States Food and Drug Administration (FDA) released a guidance document on the scope of "Part 11" enforcement. In this guidance document, the FDA indicates an expectation of a risk-based approach to determining which ...
D Moher, FDA, FDA, Rickey E Carter, T Stokes, T Stokes   +5 more
core   +3 more sources

FY-3G Satellite Instruments and Precipitation Products: First Report of China’s Fengyun Rainfall Mission In-Orbit

Journal of Remote Sensing, 2023
Precipitation is one of the most important parameters in Earth system but is hard to measure. China began to develop satellites dedicated to precipitation measurements in the second generation of the FengYun polar-orbiting meteorological satellite ...
Peng Zhang, Songyan Gu, Lin Chen, Jian Shang, Manyun Lin, Aijun Zhu, Honggang Yin, Qiong Wu, Yixuan Shou, Fenglin Sun, Hanlie Xu, Guanglin Yang, Haofei Wang, Lu Li, HongWei Zhang, Sijie Chen, Naimeng Lu   +16 more
doaj   +1 more source

Rounding up plant cells

International Journal of Plant Biology, 2010
Compared to animal cells, plant cells are typically non-spherical, which may bias morphometric and fluorimetric analyses, including flow cytometry and other approaches used in the study of cellular biodiversity.
Sergio Ochatt, Anne Moessner
doaj   +1 more source

FY-3D MERSI On-Orbit Radiometric Calibration from the Lunar View

Sensors, 2020
Limited by the on-orbital calibration capability, scaling the measured radiance in accuracy and stability is challenging for the Earth observation satellites in the reflective solar bands (RSBs).
Ronghua Wu, Peng Zhang, Na Xu, Xiuqing Hu, Lin Chen, Lu Zhang, Zhongdong Yang   +6 more
doaj   +1 more source

Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Targeting metalloproteinases has been in the focus of drug design for a long time. However, meprin α and β emerged as potential drug targets just recently and are linked to several diseases with different pathological background.
Kathrin Tan, Christian Jäger, Stefanie Geissler, Dagmar Schlenzig, Mirko Buchholz, Daniel Ramsbeck   +5 more
doaj   +1 more source

A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice

Alzheimer’s Research & Therapy, 2023
Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain.
Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W. Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cynis   +20 more
doaj   +1 more source

Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice

Biomolecules, 2022
Passive immunotherapy is a very promising approach for the treatment of Alzheimer’s disease (AD). Among the different antibodies under development, those targeting post-translationally modified Aβ peptides might combine efficient reduction in beta ...
Kathrin Gnoth, Stefanie Geissler, Julia Feldhaus, Nadine Taudte, Victoria Ilse, Sebastian Zürner, Sebastian Greiser, Ulf-Dietrich Braumann, Jens-Ulrich Rahfeld, Holger Cynis, Stephan Schilling   +10 more
doaj   +1 more source

What does validation of cases in electronic record databases mean? The potential contribution of free text [PDF]

, 2011
Electronic health records are increasingly used for research. The definition of cases or endpoints often relies on the use of coded diagnostic data, using a pre-selected group of codes.
Cassell, Jackie A, Koeling, Rob, Nicholson, Amanda, Tate, Anne Rosemary   +3 more
core   +3 more sources