Results 31 to 40 of about 1,877,790 (218)

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

open access: yesFEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri   +8 more
wiley   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

CRISPR-mediated promoter editing of a cis-regulatory element of OsNAS2 increases Zn uptake/translocation and plant yield in rice

open access: yesFrontiers in Genome Editing
Developing nutritious rice with a higher yield is one approach to alleviating the problem of micronutrient deficiency in developing countries, especially human malnutrition involving zinc and iron (Fe) deficiency, and achieving better adoption.
Yvonne Ludwig   +6 more
doaj   +1 more source

The Ground-Level Particulate Matter Concentration Estimation Based on the New Generation of FengYun Geostationary Meteorological Satellite

open access: yesRemote Sensing, 2023
The new-generation FengYun geostationary meteorological satellite has a high spatial and temporal resolution, which is advantageous in environmental assessments and air pollution monitoring.
Lin Tian   +5 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Evaluation of FY-4A Temperature Profile Products and Application to Winter Precipitation Type Diagnosis in Southern China

open access: yesRemote Sensing, 2022
FY-4A GIIRS temperature profile products have provided unprecedented information for studying the atmospheric characteristics of thermal structures since 2020.
Yang Gao   +3 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Behavioural study of PEMFC during start-up/shutdown cycling for aeronautic applications

open access: yesMaterials for Renewable and Sustainable Energy, 2019
The deployment of proton exchange membrane fuel cell (PEMFC) for aeronautic applications is a value-added energy supply alternative that not only generates useful byproducts (oxygen-depleted air, water and heat) but addresses sensitive issues such as ...
Noluntu Dyantyi   +3 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

The Application of Deep Convective Clouds in the Calibration and Response Monitoring of the Reflective Solar Bands of FY-3A/MERSI (Medium Resolution Spectral Imager)

open access: yesRemote Sensing, 2013
Based on simulated reflectance, deep convective clouds (DCC) can be used as an invariant target to monitor the radiometric response degradation of the FY-3A/MERSI (Medium Resolution Spectral Imager) reflective solar bands (RSBs).
Lin Chen, Xiuqing Hu, Na Xu, Peng Zhang
doaj   +1 more source

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