Results 101 to 110 of about 58,285,719 (241)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Imbalanced Multi-class Prediction of Student Drop-out and Graduation: A Systematic Literature Review
Journal on Efficiency and Responsibility in Education and ScienceStudent study status prediction, including drop-out and graduation, is a widely studied topic in higher education. Yet, evidence across studies remains difficult to compare due to differences in targets, imbalance treatment, metrics, and validation ...
Ridwan Setiawan +4 more
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
A descriptive analysis of research on academic bodies in the educational field
Ra XimhaiThe aim of this research is to examine the current state of studies related to Academic Bodies (ABs) for education professionals over the past decade. A detailed description of the methodologies used is provided, as well as the fundamental aspects of the
María Luisa Pereira Hernández +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Test of Gross Motor Development : Expert Validity, confirmatory validity and internal consistence
Revista Brasileira de Cineantropometria e Desempenho Humano, 2008 The Test of Gross Motor Development (TGMD-2) is an instrument used to evaluate children’s level of motordevelopment. The objective of this study was to translate and verify the clarity and pertinence of the TGMD-2 items by expertsand the confirmatory ...
Nadia Cristina Valentini +5 more
doaj
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
npj Digital MedicineDelirium affects 50% of hospitalized older adults and 80% of ICU patients, yet detection rates are as low as 20–30% with traditional methods. Natural language processing (NLP) offers potential for automated detection from clinical notes.
Ravi Shankar +3 more
doaj +1 more source