Results 101 to 110 of about 252,061 (302)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

PENGEMBANGAN MEDIA GRAFIS BERBENTUK LIFT THE FLAP BOOK SEBAGAI MEDIA PEMBELAJARAN DALAM MATA PELAJARAN IPS MATERI BENTUK MUKA BUMI DAN AKTIFITAS PENDUDUK INDONESIA

, 2016
This study aimed to: 1) produce graphic media in the form of a Lift-the-Flap book for the topic of earth surface forms and Indonesian people’s activities as Social Studies learning media for Grade VII of the junior high school (JHS); and 2) investigate ...
Ardhana, Wisnu
core  

Psychometric Properties of the Short Index of Self-actualization Scale Among Iranian Adults [PDF]

Health, Spirituality and Medical Ethics
Background and Objectives: Self-actualization is a fundamental human drive that enables individuals to realize their potential and fulfill their needs. As individual growth becomes increasingly valued, valid tools to measure self-actualization are needed.
Leili Salehi, Zahra Taheri-Kharameh, Zohreh Mahmoodi   +2 more
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

PENGEMBANGAN FILM KARTUN MATERI DAMPAK AKTIVITAS MANUSIA TERHADAP LINGKUNGAN ALAM SEBAGAI SUMBER BELAJAR IPS SISWA KELAS VII SMP

, 2016
This research aimed to: 1) develop a cartoon movie for the topic of impacts of human activities on the natural environment as a Social Studies learning resource for Grade VII students of the junior high school (JHS), and 2) investigate the ...
Puspitasari, Ratna Dwi
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

PENGEMBANGAN KARTU SEBAGAI MEDIA PEMBELAJARAN ILMU PENGETAHUAN SOSIAL SISWA KELAS VII SMP DENGAN MATERI PROSES ENDOGEN DAN EKSOGEN

, 2016
This study aimed to: 1) develop cards for Social Studies learning media for the topic of endogenic and exogenic processes for Grade VII of the junior high school (JHS), and 2) investigate the appropriateness of the cards media based on the assessment by ...
Seto, Damar Aji
core  

Validation in models of climate change and forecasting accuracy [PDF]

, 2010
Forecasting researchers, with few exceptions, have ignored the major forecasting controversy facing the world in the early 21st Century: namely, whether and by how much the earth is warming; and the role of climate modelling in reaching any conclusions ...
Kourentzes, N, Fildes, R A
core  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source