Results 131 to 140 of about 252,061 (302)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Liderança autêntica em contexto extremo: as vivências do Bope - batalhão de operações policiais especiais de Santa Catarina [PDF]

, 2015
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-graduação em Engenharia e Gestão do Conhecimento, Florianópolis, 2015Estudiosos trabalharam fortemente, na primeira década deste século, focados para o ...
Vicentini, Luiz Carlos
core  

A descriptive analysis of research on academic bodies in the educational field

Ra Ximhai
The aim of this research is to examine the current state of studies related to Academic Bodies (ABs) for education professionals over the past decade. A detailed description of the methodologies used is provided, as well as the fundamental aspects of the
María Luisa Pereira Hernández, Arturo González Torres, Virginia Mirella Zatarain Avendaño   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Tractography validation Part 2: The use of anatomical model systems and measures for validation

Tractography validation is the act of assessing and quantifying the relationship between anatomy and tractography. Validation enables the ability to assess the strengths and limitations of the fiber tractography process, and aims to ultimately understand,
Neher, Peter, Dyrby, Tim B., Palombo, Marco, Schilling, Kurt G., Anderson, Adam W., Sarubbo, Silvio, Rockland, Kathleen S., Rheault, Francois, Fieremans, Els   +8 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Towards Validation of Internet Agents

, 1997
The focus of this paper is on the validation of intelligent systems. This is a particularly hot topic, as the inability of humans to validate what they are able to design and to implement might become the limiting factor in the ability to employ those ...
Oksana Arnold, Klaus P. Jantke
core  

Natural language processing techniques to detect delirium in hospitalized patients from clinical notes: a systematic review

npj Digital Medicine
Delirium affects 50% of hospitalized older adults and 80% of ICU patients, yet detection rates are as low as 20–30% with traditional methods. Natural language processing (NLP) offers potential for automated detection from clinical notes.
Ravi Shankar, Janani Kannan, Yih Hng Tan, Qian Xu   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Dependencies in Topic Delineation and Tracking

Zitationsnetzwerke akademischer Publikationen werden zur Themenerkennung und -verfolgung mittels bibliometrischer Verfahren erstellt und zerteilt. Ergebnisse können jedoch nicht gegen eine Grundwahrheit geprüft werden. In vielen Arbeiten des Feldes fehlt
Struck, Alexander
core   +1 more source