The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
The UKCAT-12 study: educational attainment, aptitude test performance, demographic and socio-economic contextual factors as predictors of first year outcome in a cross-sectional collaborative study of 12 UK medical schools [PDF]
Most UK medical schools use aptitude tests during student selection, but large-scale studies of predictive validity are rare. This study assesses the United Kingdom Clinical Aptitude Test (UKCAT), and its four sub-scales, along with measures of ...
I C McManus +15 more
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
The Romanian translation of the Francis Scale of Attitude Toward Christianity: internal consistency reliability, re-test reliability and construct validity among undergraduate students within a Greek Orthodox Culture [PDF]
In order to contribute to a growing international research programme concerned with the correlates, antecedents and consequences of individual differences in attitude toward religion, the Francis Scale of Attitude toward Christianity was translated into ...
Ilie, Alexandra +4 more
core +1 more source
Síndrome de desgaste profesional Professional burnout syndrome
El estrés se acepta como un fenómeno necesario que hace parte de los procesos evolutivos. Un síndrome general adaptativo comprende tres fases: una reacción inicial de alarma, un estado de resistencia y una fase de agotamiento.
Neil Valentín Vega +4 more
doaj
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
In this study the concept of alignment is analyzed by presenting the results of a study that examines the degree of alignment between a standardized mathematics assessment and a set of academic standards.
Lopez, Alexis A
doaj +1 more source
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Knowledge tests for ab-initio pilot selction in civil aviation
A validity study was conducted for two purposes: to evaluate the importance of knowledge tests for pilot selection and to validate the knowledge tests of the German Aerospace Center.
Zierke, Oliver
core
Comparison of two anaerobic water polo-specific tests with the Wingate test [PDF]
The purpose of the current study was to compare 2 water polo–specific tests—the 14 3 25-m swims (SWIM) and the 30-second crossbar jumps (30CJ)—with a laboratory-based test of anaerobic power, the Wingate Anaerobic Test (WAnT).
Marrin, K. +6 more
core +1 more source

