Results 141 to 150 of about 34,671 (226)

Development and Characterisation of a Starvation‐ and Exercise‐Induced Murine Model of Microvesicular Steatosis Relevant to Anorexia Nervosa

Liver International Communications, Volume 7, Issue 1, March 2026.
ABSTRACT Anorexia nervosa (AN) leads to severe dietary restriction, low body weight, and in many patients, hepatocellular steatosis. Clinically, hepatic fat in AN is usually macrovesicular, whereas microvesicular steatosis is more often associated with severe starvation and mitochondrial dysfunction.
Michiko Ishii, Kyoko Hoshikawa, Yuko Takeda, Taketo Nishina, Fumi Uchiyama, Fumiya Suzuki, Keita Maki, Tomohiro Katsumi, Hiroaki Haga, Yoshiyuki Ueno   +9 more
wiley   +1 more source

Dlgap2 deficiency disrupts synaptic homeostasis by promoting ubiquitin-mediated Itsn1 degradation in a valproic acid-induced autism-like model. [PDF]

Sci Rep
Guo X, Zhang L, Zhuang K.
europepmc   +1 more source

Practical Applications of Secondary/Extractive Electrospray Ionization (SESI): A Versatile Tool for Real‐Time Chemical Analysis

Mass Spectrometry Reviews, Volume 45, Issue 2, Page 392-428, March/April 2026.
ABSTRACT In the 1980s, researchers discovered the remarkable ability of electrospray plumes to effectively ionize gas‐phase molecules via secondary ionization. Around 20 years later—coinciding with the ambient mass spectrometry revolution—secondary electrospray ionization (SESI) and extractive electrospray ionization (EESI) coupled to mass spectrometry
Xin Luo, Huiling Wang, Xiaolan Hu, Sasho Gligorovski, Xue Li, Pablo Sinues   +5 more
wiley   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Valproic Acid Inhibits RhoA-Mediated Vascular Smooth Muscle Cell Contraction. [PDF]

J Korean Med Sci
Park JK, Kim SH, Lee H, Hwang YJ, Cho DH.   +4 more
europepmc   +1 more source

Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö, Émeline Courtois, Anne Paakinaho, Sirpa Hartikainen, Valtteri Kaasinen, Alexis Elbaz, Anne C. M. Thiébaut, Ismaïl Ahmed, Anna‐Maija Tolppanen   +8 more
wiley   +1 more source

When Overdose Strikes: Successful Use of Hemodialysis in Valproic Acid Toxicity. [PDF]

Cureus
Zaringhalam S, Dosanjh H, Awan WA, Gower A, Takher J.   +4 more
europepmc   +1 more source

Evaluation of metabolism‐related molecules in rat model of autism spectrum disorders

Experimental Physiology, Volume 111, Issue 3, Page 1228-1241, 1 March 2026.
Abstract Autism spectrum disorders (ASD) are neurodevelopmental pathologies. Investigating both sexes is crucial for understanding sex‐specific manifestations of ASD. This study aims to examine ASD‐like behaviours and metabolic alterations in male and female rats prenatally exposed to valproic acid (VPA).
Süeda Tunçak, Ayşen Çakır, Bülent Gören, Nevzat Kahveci   +3 more
wiley   +1 more source

Neuroprotective mechanisms of valproic acid and alpha-lipoic acid in ALS: a network pharmacology-based investigation. [PDF]

Front Pharmacol
Zhang D, Han L, Zhang W, Wang D, Huo D, Tan X, Su X, Wang M, Xu J, Cheng J, Wang J, Feng H.   +11 more
europepmc   +1 more source

Beyond epilepsy: The expanding role of valproic acid in Alzheimer disease therapy - a review. [PDF]

J Pharmacol Exp Ther
Markowicz-Piasecka M, Miłkowska Z, Adla SK, Huttunen KM, Pietrzak B.   +4 more
europepmc   +1 more source