Results 141 to 150 of about 35,754 (249)

Hepatic adverse effects of valproic acid: Management strategies.

Indian J Pharmacol
Bouaziz I, Atheymen R, Sahnoun R, Ksouda K, Affes H, Hammami S, Zghal K.   +6 more
europepmc   +1 more source

Combinatorial drug repurposing of Valproic acid and Zebularine regulates Krüppel-like factor 4 and β-catenin expression in colon cancer cells. [PDF]

PLoS One
Kandhavelu J, Subramanian K, Moodley N, Abass KS, Sureka C, Kandhavelu M, Ruff P, Penny C.   +7 more
europepmc   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 673-683, September 2026.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Personalized prediction of initial valproic acid dose in children with epilepsy using machine learning techniques. [PDF]

Int J Clin Pharm
Zhang Y, Ren S, Yu J, Xu S, Zhang Y, Zhang J, Li X, Shao J, Lu L, Gao F, Tian J.   +10 more
europepmc   +1 more source

Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 721-730, September 2026.
Canada's 2009 risk management plan (RMP) framework has not been evaluated for prenatal exposure impact. Conversely, widely used drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) lack RMPs. We assessed first‐trimester exposure to RMP‐regulated medications following regulatory interventions and to NSAIDs following safety publications.
Nahiyan Saiyara Khan, Odile Sheehy, Lisiane Freitas Leal, Vanina Tchuente, Anick Bérard   +4 more
wiley   +1 more source

Modulatory effects of valproic acid and UGT polymorphisms on norclozapine plasma levels in clozapine-treated patients with schizophrenia. [PDF]

Sci Rep
Sangüesa E, Cirujeda C, Bernal A, Ribate MP, García CB.   +4 more
europepmc   +1 more source

Epilepsy‐Related Psychosis in Drug‐Resistant Epilepsy With Nonconvulsive Status Epilepticus and Difficult Antipsychotic Titration: A Case Report

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
Electroclinical findings supported diazepam‐responsive nonconvulsive status epilepticus (NCSE) in an older patient with drug‐resistant epilepsy and psychosis. After phenytoin treatment, continuous EEG helped monitor recurrence. Later symptoms were most consistent with interictal psychosis with a possible alternative psychosis component, emphasizing ...
Wataru Omori, Ryo Hirabayashi, Kenichi Oga, Yoshikazu Masuda, Go Okada   +4 more
wiley   +1 more source

The Neurotoxic Mechanisms of Valproic Acid and Their Association With Neurodevelopmental Disorders: A Narrative Review. [PDF]

Basic Clin Neurosci
Udodi PS, Abugu JI, Udodi RE, Ofoego UC, Okafor EC, Orji CE, Ezejindu DN, Oyinbo C.   +7 more
europepmc   +1 more source

Off‐Label Initiation of Gabapentin and Valproic Acid Among Long‐Stay Nursing Home Residents With and Without Dementia

Journal of the American Geriatrics Society, EarlyView.
Lauren B. Gerlach, Lan Zhang, Ana Montoya, Sarah L. Krein, Andrew R. Zullo, Julie P. W. Bynum, Donovan Maust   +6 more
wiley   +1 more source

Possible Contribution of Multiple Sclerosis Pathology to Treatment‐Resistant Schizophrenia: A Case Study

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
A case of multiple sclerosis detected by brain MRI during evaluation for modified electroconvulsive therapy in the long‐term course of schizophrenia. This case discusses the clinical overlap between multiple sclerosis pathology and treatment‐resistant schizophrenia. ABSTRACT Multiple sclerosis (MS) can present with neurological and psychiatric symptoms
Sho Miura, Atsuko Nagaoka, Mizuki Hino, Risa Shishido, Masataka Hatano, Yuto Hosogai, Kazusa Miyahara, Yuta Oba, Kimihiko Kaneko, Yasuto Kunii, Hiroaki Tomita   +10 more
wiley   +1 more source