Results 191 to 200 of about 5,054,451 (380)

Medication‐resistant epilepsy is associated with a unique gut microbiota signature

open access: yesEpilepsia, EarlyView.
Abstract Objective Dysfunction of the microbiota–gut–brain axis is emerging as a new pathogenic mechanism in epilepsy, potentially impacting on medication response and disease outcome. We investigated the composition of the gut microbiota in a cohort of medication‐resistant (MR) and medication‐sensitive (MS) pediatric patients with epilepsy.
Antonella Riva   +14 more
wiley   +1 more source

Diurnal variation in pharmacokinetics of valproic acid with unequal dosing intervals.

open access: bronze, 1988
IKUO JOHNO   +6 more
openalex   +2 more sources

Reduction of generalized tonic–clonic seizures following vagus nerve stimulation therapy: CORE‐VNS Study 24‐month follow‐up

open access: yesEpilepsia, EarlyView.
Abstract Objective Generalized tonic–clonic seizures (GTCS) are considered to be among the most devastating seizures due to increased health risks. Use of device‐based therapies, such as vagus nerve stimulation (VNS), is common for those resistant to antiseizure medications and important for those in whom resective surgery is not feasible.
Ana Suller Marti   +9 more
wiley   +1 more source

MBOAT7 encephalopathy: Characterizing the neurology and epileptology

open access: yesEpilepsia, EarlyView.
Abstract Objective Biallelic pathogenic MBOAT7 variants are associated with neurodevelopmental disorders, intellectual disability (ID), epilepsy, and neuropsychiatric disorders such as attention‐deficit/hyperactivity disorder and autism spectrum disorders. We aimed to characterize the epilepsy phenotype in a cohort of patients affected by this syndrome.
Sebastian Ortiz De la Rosa   +28 more
wiley   +1 more source

Expanding the therapeutic role of highly purified cannabidiol in monogenic epilepsies: A multicenter real‐world study

open access: yesEpilepsia, EarlyView.
Abstract Objective This real‐world, retrospective, multicenter study aims to investigate the effectiveness of highly purified cannabidiol (CBD) in a large cohort of patients with epilepsy of genetic etiology due to an identified monogenic cause. Additionally, we examine the potential relationship between specific genetic subgroups and treatment ...
Emanuele Cerulli Irelli   +68 more
wiley   +1 more source

Simultaneous determination of asenapine and valproic acid in human plasma using LC–MS/MS: Application of the method to support pharmacokinetic study

open access: yesJournal of Pharmaceutical Analysis, 2013
Combination of asenapine with valproic acid received regulatory approval for acute treatment of schizophrenia and maniac episodes of bipolar disorders.
Ambavaram Vijaya Bhaskar Reddy   +2 more
doaj  

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