Results 71 to 80 of about 34,041,313 (284)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Frequently Asked Questions Related to the Commission on Evidence-Based Policymaking's Report
, 2017 List of frequently-asked questions regarding the final report of the U.S. Commission on Evidence-Based Policymaking with answers and clarifications. Questions are broken into five topics: general, National Secure Data Service (NSDS), privacy, access ...
United States. Commission on Evidence-Based Policymaking.
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
MEASURING PERFORMANCE, VALUE CREATION AND VALUE-BASED MANAGEMENT IN THE CONTEXT OF COMPETITIVENESS AND GLOBALIZATION [PDF]
In times of uncertainty, knowing the best methods of measuring performance and creating value, determines the increase competitiveness of companies.
Prof. Vasile Robu, Ph. D +1 more
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What's significant in value based management: an internal perspective.
, 2006 The subject of Value Based Management (VBM) in general, and Economic Value Added (EVATM) in particular, is one that is assuming increasing significance in both the academic and practitioner environments.
Brown, James
core +1 more source
Value-Based Inventory Management [PDF]
SSRN Electronic Journal, 2013 The basic financial purpose of a firm is to maximize its value. An inventory management system should also contribute to realization of this basic aim. Many current asset management models currently found in financial management literature were constructed with the assumption of book profit maximization as basic aim.
openaire +4 more sources
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
RESOURCE SUPPORT OF VALUE BASED MANAGEMENT
Вісник Київського національного університету імені Тараса Шевченка. Серія Економіка, 2015 The paper encapsulates the essence of the resource providing value based management at the enterprises. The study explores the nature and components of diagnostic resources of the enterprise.
T. Kravchenko
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source