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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source
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The Value of Values for Institutional Analysis

Academy of Management Annals, 2020
Although values were once the central focus of institutional scholarship, they occupy a marginal position in the contemporary literature.
Matthew S. Kraatz   +2 more
openaire   +1 more source

Value of Information Analysis in Oncology: The Value of Evidence and Evidence of Value

Journal of Oncology Practice, 2014
Benefits in oncology research and practice will potentially be optimized with increased application of VOI methods to inform decision making, optimal trial design, and research prioritization.
Tuffaha, Haitham W.   +2 more
openaire   +5 more sources

The Value of Value Analysis

Oxford Literary Review, 1978
labour is itself cont ingent on the original specification of the exchange of commodi t ies as the making-identical of those commodi t ies , as the revelation of their essence, Le. human labour. This is where the real problem lies (as Cutler, Hindess, Hirst and Hussain show hereafter CHHH of p roduc t ion can be determined from the specifi­ cation of ...
openaire   +1 more source

The value of bite analysis

The Journal of the American Dental Association, 1954
Bite analysis is, briefly, an examination of the human bite with reference to ar­ ticulation and stress. Such an analysis should precede any attempt to restore or reconstruct an individual dentition. Nat­ urally, all other factors associated with the functional efficiency of the bite must be taken into account also, such as inci­ dence of caries, oral ...
openaire   +2 more sources

Extreme value analysis in biometrics

Biometrical Journal, 2009
AbstractWe review some approaches of extreme value analysis in the context of biometrical applications. The classical extreme value analysis is based on iid random variables. Two different general methods are applied, which will be discussed together with biometrical examples.
openaire   +4 more sources

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