Results 31 to 40 of about 1,486,301 (262)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Determinants of marketed surplus of field pea among smallholder farmers in Jabi Tehnan woreda, West Gojjame zone, Ethiopia

Discover Sustainability
Field peas play a substantial role in the socioeconomic lives of both the urban and rural society in Ethiopia. It is the cheapest source of protein, food security and a source of cash income. However, the field pea marketing system is under developed and
Mamaru Abebe, Seblewongiel Solomon
doaj   +1 more source

Determining Factors for Supply Chain Services Provider Selection and Long-Term Relationship Maintenance: Evidence from Greece

Logistics, 2023
Background: Due to increased globalization and its subsequent rise in competitiveness, the role of supply chain services (3PL) in managing logistics, reducing operational and non-operational costs, and managing customer and supplier relationships, have ...
Damianos P. Sakas, Nikolaos T. Giannakopoulos, Nikos Kanellos, Christos Christopoulos, Kanellos S. Toudas   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Does Adoption of Multiple Climate‐Smart Agriculture Practices Improve Rural Farm Households' Food Security in Ethiopia?

Food and Energy Security
Climate‐smart agriculture (CSA) is a set of economically and environmentally friendly practices that can address the issues of food security under the new realities of climate change.
Tibebu Legesse, Zerhun Ganewo, Abera Alemu, Aneteneh Ashebir, Andachew Samuel, Yaynabeba Abayneh   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Determinants of adoption of grafted avocado (Persea americana Miller) varieties from bure and Jabitehnan districts, west Gojjam zone, Ethiopia

Discover Food
Avocado fruits provide a significant nutritional and economic benefit for rural households; however, the factors that influence adoption of grafted avocado varieties and the intensity of adoption require further investigation in the study area. The study
Gizachew Wosene, Wubalem Gobie, Wondye Mengistu, Tegbew Walle, Asrebeb Sahle   +4 more
doaj   +1 more source

Can high-value markets ensure households food security? Evidence from avocado producers in Sidama Region of Ethiopia

Cogent Social Sciences
Linking farmers to high-value markets continue to be a viable option for breaking the food insecurity. Many studies have emphasized on factors determining smallholders’ participation in high-value markets. Previous studies have methodological limitations
Tibebu Legesse, Kehabtimer Kebede, Aneteneh Ashebir, Zerhun Ganewo, Abera Alemu, Andachew Samuel   +5 more
doaj   +1 more source