Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The potential of shared value creation: a theoretical analysis
Romanian Economic Journal, 2016 The urgent issues economy, environment and society are facing need new approaches which allow a well-balanced sharing of value created by the economy. A step forward is the concept of shared value creation.
Victor Danciu
doaj
From Cultural Tourism to Social Entrepreneurship: Role of Social Value Creation for Environmental Sustainability. [PDF]
Front Psychol, 2022 Li X +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
What's in it for me? A mixed-methods study on teachers' value creation in an inter-institutional community on open educational resources in higher education. [PDF]
Educ Inf Technol (Dordr), 2023 Baas M +6 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Shareholders and stakeholders value creation: an analytic foundation for value creation indicators
PSL Quarterly Review, 2007 Article originally published in the volume 60 issue 240 of Banca Nazionale del Lavoro Quarterly Review (also known as BNL Quarterly Review).
Giancarlo Mazzoni, Rainer S. Masera
doaj
Toward Economic Growth and Value Creation Through Social Entrepreneurship: Modelling the Mediating Role of Innovation. [PDF]
Front Psychol, 2022 Wang W.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Value in psoriasis (IRIS) trial: implementing value-based healthcare in psoriasis management - a 1-year prospective clinical study to evaluate feasibility and value creation. [PDF]
BMJ Open, 2023 Hilhorst N +7 more
europepmc +1 more source