Results 51 to 60 of about 3,066,509 (354)

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser   +6 more
wiley   +1 more source

To generate functional anti-protease-activated receptor-4 (PAR4), a G protein-coupled receptor, antibodies through PAR4-mRNA-LNP immunization

open access: yesnpj Vaccines
G protein-coupled receptors (GPCRs) are key therapeutic targets for various diseases, such as the thrombin receptor protease-activated receptor 4 (PAR4) involved in thrombotic cardiovascular disorders.
En-Shuo Liu   +14 more
doaj   +1 more source

Value Creation along a Production-Service Value Chain

open access: yesInternational Journal of Engineering and Management Sciences, 2022
Today’s products and services are so complicated and intertwined that their individual value creation is hard to determine. It is especially true when the products and services are necessary complements of each other and when they are affecting customer
Teréz Gerse-Krizsa, Noémi Kalló
doaj   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack   +12 more
wiley   +1 more source

Psychological Safety Among Interprofessional Pediatric Oncology Teams in Germany: A Nationwide Survey

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events.
Alexandros Rahn   +4 more
wiley   +1 more source

The Role of Empathetic Company Philosophy and Advanced Technologies in Shaping Job Attitudes

open access: yesBusiness Systems Research
Although the literature has assessed various factors underlying employee attitudes, knowledge of company philosophy and advanced technology is lacking, especially in the context of the major drivers of job satisfaction and turnover intentions.
Koizumi Masaki, Kato Takumi
doaj   +1 more source

Developmental Disorders in Children Recently Diagnosed With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016–2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer‐free controls.
Jamie Shoag   +5 more
wiley   +1 more source

Dietary heat‐killed Lactobacillus brevis SBC8803 (SBL88™) improves hippocampus‐dependent memory performance and adult hippocampal neurogenesis

open access: yesNeuropsychopharmacology Reports, 2019
Aims Lactobacillus species are used widely as various food and supplements to improve health. Previous studies have shown that heat‐killed Lactobacillus brevis SBC8803 induces serotonin release from intestinal cells and affects sleep rhythm and the ...
Rie Ishikawa   +4 more
doaj   +1 more source

Predicting the Future Burden of Renal Replacement Therapy in Türkiye Using National Registry Data and Comparative Modeling Approaches

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic kidney disease is a growing public health problem worldwide, and the number of patients requiring renal replacement therapy is steadily increasing. Türkiye has experienced a similar rise in both the incidence and prevalence of renal replacement therapy over the past decades; however, national‐level projections of future ...
Arzu Akgül   +2 more
wiley   +1 more source

Business Value Is not only Dollars - Results from Case Study Research on Agile Software Projects [PDF]

open access: yes, 2010
Business value is a key concept in agile software development. This paper presents results of a case study on how business value and its creation is perceived in the context of agile projects.
A. Aurum   +14 more
core   +3 more sources

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