Results 61 to 70 of about 583,925 (313)
npj VaccinesG protein-coupled receptors (GPCRs) are key therapeutic targets for various diseases, such as the thrombin receptor protease-activated receptor 4 (PAR4) involved in thrombotic cardiovascular disorders.
En-Shuo Liu +14 more
doaj +1 more source
Intraocular Pressure Measurement with Pneumatonometry and a Tonometer Tip Cover
Ophthalmology and Therapy, 2020 Purpose To investigate the precision and accuracy of IOP measurements using a pneumatonometer and a tonometer tip cover (Tono-Pen® tip cover) acting as a membrane between a cadaver eye model and pneumatonometer probe.
Tanner J. Ferguson +8 more
doaj +1 more source
Value Creation and the Entrepreneurial Business [PDF]
The Journal of Entrepreneurial Finance, 2002 The need to finance high growth and manage the interests and needs of investors makes value creation a critical concern for entrepreneurial businesses. Almost any financial endeavor, such as attracting new investors or making investment decisions, necessitates the consideration of the equity value created by the endeavor.
Spivey, Michael F., McMillan, Jeffrey J.
openaire +3 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Conceptualising capabilities and value co-creation in a digital business ecosystem (DBE): a systematic literature review [PDF]
, 2020 Digital Business Ecosystem (DBE) is a topical concept for business organisations to collaborate in driving product or service innovation. DBE is supported by digital technologies which aim to create and co-create values among the participated business ...
Binita, Ghale +2 more
core +1 more source
The Role of Empathetic Company Philosophy and Advanced Technologies in Shaping Job Attitudes
Business Systems ResearchAlthough the literature has assessed various factors underlying employee attitudes, knowledge of company philosophy and advanced technology is lacking, especially in the context of the major drivers of job satisfaction and turnover intentions.
Koizumi Masaki, Kato Takumi
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Value Creation in International Joint Ventures: Impact of Inter-Partner Factors and Location
, 2016 One key goal when establishing international joint ventures (IJVs) is to create value in different ways for the partnering firms. The value creation can be via new innovations, more effective production processes, taking benefit of the synergy effects in
Ali, Tahir, +5 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source