Results 51 to 60 of about 7,652,135 (241)
Ab locks for improving the selectivity and safety of antibody drugs
Journal of Biomedical Science, 2020 Monoclonal antibodies (mAbs) are a major targeted therapy for malignancies, infectious diseases, autoimmune diseases, transplant rejection and chronic inflammatory diseases due to their antigen specificity and longer half-life than conventional drugs ...
Wen-Wei Lin +3 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The Role of Empathetic Company Philosophy and Advanced Technologies in Shaping Job Attitudes
Business Systems ResearchAlthough the literature has assessed various factors underlying employee attitudes, knowledge of company philosophy and advanced technology is lacking, especially in the context of the major drivers of job satisfaction and turnover intentions.
Koizumi Masaki, Kato Takumi
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Intraocular Pressure Measurement with Pneumatonometry and a Tonometer Tip Cover
Ophthalmology and Therapy, 2020 Purpose To investigate the precision and accuracy of IOP measurements using a pneumatonometer and a tonometer tip cover (Tono-Pen® tip cover) acting as a membrane between a cadaver eye model and pneumatonometer probe.
Tanner J. Ferguson +8 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Journal of Translational Medicine(Background) CD47 is highly expressed on many cancer cells and acts as an innate immune checkpoint. Its binding to signal regulatory protein alpha (SIRPα) on macrophages enables cancer cells to evade phagocytosis.
Yu-Tung Chen +12 more
doaj +1 more source
VALUE CREATION AND RESOURCE-BASED VIEW
, 2010 A PRESENTATION OF LINKAGES BETWEEN VALUE CREATION STUDIES AND RESOURCE-BASED ...
SCIARELLI, MAURO
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source