Results 71 to 80 of about 7,652,135 (241)

Living labs: a systematic review of success parameters and outcomes

Buildings & Cities
Living labs (LLs) have emerged as a prominent vehicle for open, user-centric innovation; however, systematic evaluations of their effectiveness remain scarce. This assessment gap is addressed by conducting a systematic literature review that assesses the
Jan Moritz Müller
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Investing for long-term value creation [PDF]

, 2019
In the transition to a sustainable economy, companies are increasingly adopting the goal of long-term value creation, which integrates financial, social and environmental value.
Schoenmaker, Dirk, Schoenmaker, Dirk; id_orcid, Schramade, W.L.J. (Willem), Schoenmaker, D. (Dirk), Schramade, W   +4 more
core   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

An Empirical Study of Value Creation Criteria: Case of Iran [PDF]

Today’s investors, creditors, and managers are look for an on-time and reliable index, with the goal of evaluating value creation amount. The aim of this study is inducing of voluble measures to users and increasing their understanding yielded these ...
Hashem VALIPOUR, Zahra YOUSEFI, Mahdi SALEHI, Godratallah TALEBNYA   +3 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

What You Eat Reveals Who You Are:

Maketingu Janaru
We propose that food choice may serve as a categorical basis for an individual’s self-identity, meaning “what you eat reveals who you are.” This type of social identity, namely, food identity (FI), can be a significant determinant of consumers’ attitudes
Minoru Karasawa, Kazutoshi Sasahara, Hakche Ryu   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The influence of managerial coaching on employee expertise: promoting work motivation as a mediator [PDF]

International Journal of Human Capital in Urban Management
BACKGROUND AND OBJECTIVES: The current organizational environment, extreme competition, and rapid change in the working environment have increased the motivation of researchers to identify important variables that can help organizations to be competitive
N. Mohamad, S. Sanusi, A. Othman
doaj   +1 more source